摘要
目的探讨经阴道彩色多普勒超声(TVCDS)结合血清肿瘤标志物HE4、CA125检测对卵巢癌早期诊断的临床应用价值。方法选取临床拟诊为附件肿块而入院行择期手术的患者151例,根据术后病理诊断结果分为A组(卵巢癌组)48例和B组(卵巢良性病变组)103例。手术前所有患者均接受TVCDS检查以及血清HE4、CA125水平的测定,并与手术治疗后的病理诊断结果作比较分析。结果 A组患者的血清HE4、CA125水平与B组患者比较均大幅度升高;TVCDS参数S/D、PI及RI与B组患者比较均明显降低。TVCDS、HE4、CA125联合对卵巢癌进行诊断时总一致性、敏感性、特异性、阳性预测值、阴性预测值分别为94.70%、93.75%、95.15%、90.00%、97.03%,且高于单独检查时的值。结论 TVCDS结合血清HE4、CA125水平测定有助于卵巢癌临床诊断水平的提高。
Objective To estimate the clinical value of diagnosing early ovarian cancer by using transvaginal color doppler sonography（ TVCDS）,combined with the levels of serum tumor markers HE4 and CA125. Methods A total of 151 patients with adnexal masses admitted for elective surgery were selected. According to the postoperative pathologic results,they were divided into ovarian cancer group（ group A,48 cases） and ovarian benign lesions group（ group B,103 cases）. All patients were examined by TVCDS and the determination of serum HE4 and CA125 level before surgery. The results were compared with pathological diagnosis after surgery. Results Serum HE4 and CA125 levels of the patients in group A were higher than those in group B. TVCDS parameters S / D,PI and RI were significantly lower in group A than in group B. The accuracy,sensitivity,specificity,positive predictive value,negative predictive value of TVCDS and HE4 ＋ CA125 in ovarian cancer diagnosis were 94. 70%,93. 75%,95. 15%,90. 00%,97. 03%,respectively. The values were higher than the value of the separate checks. Conclusion TVCDS combined determination of serum HE4 and CA125 level is helpful to the improvement of clinical diagnosis in ovarian cancer.
出处
《上海预防医学》
CAS
2016年第6期372-375,共4页
Shanghai Journal of Preventive Medicine
作者简介
白彦霞（1980-），女，主治医师，学士
【通信作者】汤海红，E-mail：tanghaihong2015@163．com
