摘要
细胞自噬(autophagy)是一个在各种外界因素影响下,真核细胞通过溶酶体降解其内部受损的细胞器、错误折叠的蛋白质和侵入其内的病原体并产生可以重新参与生命活动的物质和能量的生物学过程,在维持机体内环境稳定等方面发挥着重要的作用。目前,我国食管癌患者的发病率和病死率均远高于世界平均水平,放化疗联合靶向药物治疗已逐渐应用于食管癌的临床治疗,而这些新兴治疗措施与细胞自噬有着一定的关系。该文就细胞自噬在食管癌发生发展中的作用和调控机制进行综述。
Autophagy is one of the biological processes that under the influence of various external factorseukaryotic cells degrade damaged organellesunfolded proteins and intracellular pathogens to lysosomes as well as provide the cells with nutrients and energy which can re-engage life activities. Autophagy plays an important role in maintaining homeostasis and so on.At presentthe incidence and mortality rates of esophageal cancer in China are much higher than the world average.The radiotherapy and chemotherapy combined with targeted therapy have gradually gained wide application in the treatment of esophageal cancerand these novel therapeutic measures are related to cell autophagy.The regulatory mechanism of autophagy in the development of esophageal cancer is introduced in this paper.
出处
《中华胸部外科电子杂志》
2016年第1期46-50,共5页
CHINESE JOURNAL OF THORACIC SURGERY：Electronic Edition
作者简介
通讯作者：束余声,Email：shuyusheng65@163.com
