摘要
目的通过随访长期存活急性PQ中毒患者在中毒后6个月的肺功能以进一步了解PQ中毒致肺损伤的转归。方法回顾河北医科大学第二医院急诊科于2010年9月至2012年7月收治的50例PQ中毒患者，按临床及肺cT表现分为轻型组和重型组，在中毒后6个月时测定vc％、FVC％、FEV1．0％、FEV1．0／FVC％、MMEF％，应用SPSS20．0软件进行统计分析，观察两组肺功能的差别。结果轻型组VC％为（93．28±7．11）％，FVC％为（94．24±7．17）％，FEV1．0％为（96．48±8．85）％，FEV1．0／FVC％为（97．83±8．21）％，MMEF％为（102．82±9．52）％；重型组VC％为（97．13±12．18）％，FVC％为（98．94±12．22）％，FEV1．0％为（99．52±12．84）％，FEV1．0／FVC％为（90．18±7．88）％，MMEF％为（91．48±11．80）％。轻型组与重型组限制性、阻塞性通气障碍异常率的比较均差异无统计学意义（P〉0．05）；轻型组与重型组肺功能各检测指标异常率的比较均差异无统计学意义（P〉0．05）；轻型组与重型组FEV1．0／FVC％、MMEF％比较差异有统计学意义（P〈0．05），其他指标均差异无统计学意义（P〉0．05）。结论百草枯中毒可对存活至6个月的部分患者的肺功能造成一定损伤，对重型患者小气道造成的损伤程度较轻型患者为重，但这种差异未能使阻塞性通气障碍异常率差异具有统计学意义。
Objective To further study the prognosis of paraquat （PQ） induced lung injury by means of the follow-up of the pulmonary function at 6 months poisoning in long-term survival patients with acute PQ poisoning. Methods The data of 50 PQ poisoning patients admitted from September 2010 to July 2012, and were retrospectively reviewed, and the patients were divided into the mild group and the severe group according to the manifestations and pulmonary CT. The measurement of VC% （ vital capacity） , FVC% （forced vital capacity）, FEVI. 0% （forced expiratory volume）, FEV1.0/FVC%, and MMEF% （maximal mid-expiratory flow ） were determined at 6 months after PQ poisoning. The comparison of pulmonary function between two groups was made by statistical analysis with SPSS 20. 0 software. Results VC%, FVC%, FEVI. 0%, FEVI.0/FVC% and MMEF% was （93.28 ±7.11）%, （94.24±7.17, 96）%. （48 ±8.85）%, （97.83 ±8.21 ） % and （ 102. 82±9. 52）% respectively in mild group. VC%, FVC%, FEV1.0%, FEVI. 0/FVC% and MMEF% was （97.13 ±12. 18）%, （98.94 ± 12. 22）%, （99.52± 12.84）%, （90.18 ±7.88） %and （91.48 ± 11.80） %respectively in severe group. The abnormal rate of restrictive or obstructive ventilatory disorder in mild group showed no significant difference with that in severe group （ P 〉 0. 05 ）. The abnormal rate of indexes of the lung function in mild group showed no significant difference with that in severe group （ P 〉 0. 05 ）. FEV1. 0/FVC% and MMEF% inmild group showed statistically difference with that in severe group （P 〈 0. 05 ）. The other indexes in mild group showed no significant difference with that in severe group （ P 〉 0. 05 ）. Conclusions PQ poisoning can cause damage to a certain extend to pulmonary function in survival patients at 6 months. The extent of the damage to the small airways in severe group was more grave than that in mild group. However, this difference could not make the abnormal rate of obstructive ventilatory disorder any statistical difference.
出处
《中华急诊医学杂志》
CAS
CSCD
北大核心
2016年第6期792-796,共5页
Chinese Journal of Emergency Medicine
基金
河北省科技计划项目（12277709）
关键词
中毒
百草枯
肺功能
肺损伤
肺纤维化
Poisoning
Paraquat
Pulmonary Function
Lung Injury
Lung Fibrosis
作者简介
通信作者：田英平，Email：tianyingping_jzh@163．com
