摘要
目的：分析丹参注射液辅助治疗病毒性心肌炎的抗炎及抗氧自由基的效应。方法：将2014年1月~2016年1月间在本院接受治疗的病毒性心肌炎患儿90例纳入研究,根据治疗方案不同随机分为观察组及对照组各45例。对照组患儿接受临床病毒性心肌炎常规治疗,观察组患儿接受丹参注射液辅助治疗,对比两组患儿的IL23/IL-17炎症轴及细胞因子、氧化及抗氧化指标、心肌酶谱及病情相关蛋白水平。结果：观察组患儿的血清IL-17、IL-23、IL-1β、IL-6、TNF-α值均低于对照组患儿（均P〈0.05）;观察组患儿的治疗后血清MDA、AOPP、NO值低于对照组患儿,SOD、T-AOC值高于对照组患儿（均P〈0.05）;观察组患儿的治疗后血清cTnT、CK-MB、MCP-1、H-FABP值均低于对照组患儿（均P〈0.05）。结论：病毒性心肌炎患儿接受丹参注射液辅助治疗,可以发挥积极的抗炎及抗氧自由基功能,在心肌保护方面具有积极意义。
Objective：To analyze the anti-inflammation and anti-oxygen free radical effect of adjuvant Danshen injection treatment on viral myocarditis.Methods：A total of 90 children with viral myocarditis treated in our hospital from January 2014 to January 201 6 were included in the research and randomly divided into observation group （n =45）and control group （n =45） according to the different treatment.Control group received clinical routine therapy for viral myocarditis,observation group re-ceived adjuvant Danshen injection treatment,and then levels of IL23/IL-1 7 inflammatory axis as well as cytokines,oxidation and anti-oxidation indexes,myocardial enzyme and illness-related proteins were compared between two groups.Results：Serum IL-1 7,IL-23,IL-1β,IL-6 and TNF-αvalues of observation group were lower than those of control group （P 〈0.05）;serum MDA,AOPP and NO values of observation group after treatment were lower than those of control group while SOD and T-AOC values were higher than those of control group （P 〈0.05）;serum cTnT,CK-MB,MCP-1 and H-FABP values of obser-vation group after treatment were lower than those of control group （P 〈0.05）.Conclusions：Adjuvant Danshen injection treat-ment for children with viral myocarditis can exert positive anti-inflammation and anti-oxygen free radical function,and it plays a positive role in myocardial protection.
出处
《海南医学院学报》
CAS
2016年第15期1630-1632,1636,共4页
Journal of Hainan Medical University
基金
2012年广东省建设中医药强省科研课题(20122095)~~
作者简介
梁文宝（1980-），男，广东中山人，主治医师，学士，电话：855960358280、13715680872，Email：liangbaobao0872@sina．com。
