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7种细胞因子对体外受精-胚胎移植妊娠结局的影响 被引量:4

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摘要 目的了解胰岛素样生长因子2(IGF-2)、白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、白血病抑制因子(LIF)、血管内皮生长因子(VEGF)、肿瘤坏死因子α(TNF-α)和转化生长因子β1(TGF-β1)7种细胞因子对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法用ELISA法检测接受IVF-ET者卵泡液、取卵日血清以及移植日血清中7种细胞因子浓度水平,比较分析临床妊娠成功和未临床妊娠两组7种细胞因子浓度水平。用化学发光法检测卵泡液中雌二醇、孕酮和睾酮浓度。结果未临床妊娠组卵泡液中VEGF和TGF-β1浓度均高于临床妊娠组(P均<0.05)。卵泡液中VEGF浓度与雌二醇、睾酮浓度呈负相关(r分别为-0.161、-0.224,P均<0.05)。卵泡液中TGF-β1浓度与睾酮、IL-1β、IL-6和TNF-α浓度呈正相关(r分别为0.162、0.716、0.405、0.402,P均<0.05)。结论卵泡液中VEGF和TGF-β1的浓度水平可能影响IVF-ET妊娠结局。
出处 《临床检验杂志》 CAS CSCD 2016年第3期193-195,共3页 Chinese Journal of Clinical Laboratory Science
基金 湖北省科技厅资助项目(2009CDA065)
作者简介 胡兴文,1969年生,男,主任技师,大学本科,主要从事临床检验工作。
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