摘要
目的:分析慢性阻塞性肺疾病合并支气管扩张患者的临床特征,提高对该病的认识和诊断水平。方法:选择我院2007年1月至2014年12月,就诊住院的慢性阻塞性肺疾病患者260例为研究对象,分为慢性阻塞性肺疾病组(n=134例),慢性阻塞性肺疾病合并支气管扩张组(n=126例),比较两组患者在临床表现、胸部高分辨CT、肺功能检查结果及实验室检查等方面的差异。结果:两组患者在年龄、性别、吸烟指数、体质量指数及基础药物治疗等方面,均差异无统计学意义(P>0.05)。合并支气管扩张患者肺功能FVC%预计值、FEV1%预计值、FEV1/FVC%预计值、DLCO/VA%预计值较未合并支气管扩张组低,而RV%预计值、TLC%预计值、RV/TLC%预计值高于未合并支气管扩张组(P<0.05),且出院后6个月内发生急性加重的次数多,呼吸困难评分(m MRC)高(P<0.05)。结论:合并支气管扩张的慢性阻塞性肺疾病患者肺功能下降更为明显,发生急性加重的风险增加。
Objective： To investigate the clinical characteristics of chronic obstructive pulmonary disease（ COPD） patients complicated with bronchiectasis,so as to improve the understanding and diagnosis of the disease. Methods： 260 cases of patients with COPD were enrolled from January 2007 to December 2014 in our hospital,who divided into two groups,COPD group（ n = 134） and COPD with bronchiectasis group（ n =126）. To compare their clinical characteristics,HRCT,respiratory function tests and laboratory examinations.Results： There is no difference between the two groups in age,sex,smoking index,body mass index（ BMI）,bascal drug treatment（ P〉0. 05）. The FVC% predicted,FEV1% predicted,FEV1/ FVC% predicted,DLCO /VA% predicted were lower in the COPD with bronchiectasis group than the COPD group. But the RV% predicted,TLC% predicted,RV / TLC% predicted were higher in the COPD with bronchiectasis group than the COPD group（ P〈0. 05）. The acute exacerbation within 6 months after discharged from the hospital more times and the dyspnea score（ m MRC） higher in the COPD with bronchiectasis group than the COPD group（ P〈0. 05）.Conclusion： The results shows respiratory function tests worse,the risk of acute exacerbation more often in the COPD patients with bronchiectasis than the COPD patients.
出处
《心肺血管病杂志》
2016年第4期275-278,共4页
Journal of Cardiovascular and Pulmonary Diseases
基金
北京市科委首都临床特色应用研究基金(编号:Z131107002213109)
关键词
肺疾病
阻塞性
支气管扩张
肺功能检查
Pulmonary disease
Chornic obstructive
Bronchiectasis
Respiratory function tests
作者简介
通信作者：刘双，主任医师，教授，博士生导师，主要从事呼吸危重症的诊疗和研究工作。E-mail：liushuang862002@163．com
