初诊多囊卵巢综合征患者空腹血清Pentraxin3的水平变化及意义被引量：2

Changes and significance of fasting serum Pentraxin3 levels in patients with newly-diagnosed polycystic ovarian syndrome

在线阅读下载PDF

导出

摘要目的检测初诊多囊卵巢综合征(PCOS)患者空腹血清Pentraxin3(PTX3)水平,探讨其在PCOS发生发展中的可能作用。方法选取78例PCOS患者(PCOS组)和67例健康体检者(对照组),两组按体质指数(BMI)分为体重正常(PCOS-NW,对照-NW)亚组和超重/肥胖(PCOS-OW/OB,对照-OW/OB)亚组。测量身高、体重、腰围(WC)、臀围。测定各组空腹血清PTX3水平、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)、空腹血糖(FBG)、餐后2 h血糖(P2hB G)、空腹胰岛素(FINS);计算BMI、腰臀比(WHR)、稳态模型胰岛素抵抗指数(HOMA-IR)。结果(1)PCOS组和对照组中OW/OB组PTX3水平均低于NW组(P<0.05,P<0.01);(2)Pearson相关性分析显示空腹血清PTX3水平与BMI、FBG、P2hB G、FINS、HOMA-IR呈负相关性(P<0.05);(3)多元回归分析结果显示影响PTX3水平的重要因素是FBG;(4)二分类Logistic回归分析显示PTX3是PCOS发生的保护因素。结论 PTX3可能参与了PCOS的发生,低水平的PTX3可能是PCOS发生发展中的危险因素。 Objective To evalute the variation of fasting serum Pentraxin3（ PTX3） levels and its role in the development of patients with newly-diagnosed polycystic ovarian syndrome（ PCOS）. Methods 78 patients and 67 healthy subjects were selected and each group was divided into normal weight subgroup（ PCOS-NW,control-NW） and overweight / obese subgroup（ PCOS-OW / OB,control-OW / OB） according to the body mass index（ BMI）. Height,weight,waist circumstance（ WC） and hip circumference were measured. Serum PTX3 level,total cholesterol（ TC）,triglyceride（ TG）,high-density lipoprotein（ HDL）,low-density lipoprotein（ LDL）,luteinizing hormone（ LH）,follicle stimulating hormone（ FSH）,testosterone（ T）,fasting blood glucose（ FBG）,postprandial 2 h blood glucose（ P2 h BG）,fasting insulin（ FINS） were also measured. BMI,waist-hip ratio（ WHR） and homeostasis model assessment of insulin resistance（ HOMA-IR） were calculated. Results 1 Fasting serum PTX3 levels in PCOS-OW / OB and control-OW / OB were significantly lower than those in PCOS-NW and control-NW（ P 〈0. 05,P 〈0. 01）; 2Fasting serum PTX3 level was found correlated negatively with BMI,FBG,P2 h BG,FINS and HOMA-IR（ P〈 0. 05）; 3 Multiple stepwise regression analysis demonstrated that FBG was the influencing factor of serum PTX3level; 4 Binary logistic regression analysis showed that PTX3 was the protective factor of PCOS. Conclusion The serum PTX3 level may play a very important role in the development of PCOS. Lower PTX3 level may be a risk factor in the development of PCOS.

作者张雨胡红琳王岩王长江

机构地区安徽医科大学第一附属医院内分泌科

出处《安徽医科大学学报》 CAS 北大核心 2016年第6期883-887,共5页 Acta Universitatis Medicinalis Anhui

基金中华医学会临床医学科研专项资金项目(编号:13040420427) 安徽高校省级科学研究项目(编号:KJ2013Z126)

关键词多囊卵巢综合征胰岛素抵抗 Pentraxin3 polycystic ovary syndrome insulin resistance Pentraxin3

分类号 R711.75 [医药卫生—妇产科学]

作者简介张雨，女，硕士研究生；胡红琳，女，副主任医师，硕士生导师，责任作者，E—mail：hhlin1994@sina．com 王长江，男，主任医师，硕士生导师，责任作者，E—mail：ehjw82@126．com；

引文网络
相关文献

参考文献15

1Lumeng C N, Sahiel A R. Inflammatory links between obesity and metabolic disease [ J ]. J Clin Invest,2011 , 121 (6) : 2111 - 7.
2Younis A, Hawkins K, Mahini H,et al. Serum tumor necrosis fac- tor-t2, interleukin, monoeyte chemotactic protein-1 and paraoxo- nase-1 profiles in women with endometriosis, PCOS, or unex- plained infertility[ J]. J Assist Reprod Genet,2014,31 ( 11 ) : 1445 -51.
3Todoric J , Handisurya A, Knapp B, et a[. Relationship of pen- traxin 3 with insulin sensitivity in gestational diabetes [ J ]. Eur J Clin Invest,2013,43(4) :341 -9.
4Karakas M F, Buyukkaya E, Kurt M, et al. Serum pentraxin-3 levels are associated with the severity of metabolic syndrome [ J ].Med Princ Pract ,2013, 22(3) : 274 -9.
5Breviario F, d'Aniello E M, Golay J,et al. Interleukin-l-inducible genes in endothelial cells. Cloning of a new gene related to C-reac- tive protein and serum amyloid P component [ J ]. J Biol Chern, 1992,267 (31) :22190 -7.
6Garlanda C, Bottazzi B, Bastone A, et al. Pentraxins at the cross- roads between innate immunity, inflammation, matrix deposition, and female fertility [ J ]. Annu Rev Immunol,2005,23 : 337 - 66.
7Tosi F, Di Sarra D, Bonin C, et al. Plasma levels of pentraxin-3, an inflammatory protein involved in fertility, are reduced in women with polyeystic ovary syndrome [ J ]. Eur J Endoerinol, 2014,170 (3) : 401 -9.
8Varani S, Elvin J A, Yan C, et al. Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility [ J ]. Mol Endoerino1,2002,16 ( 6 ) : 1154 - 67.
9Slusher A L,Mock J T, Whitehurst M,et al. The impact of obesity on pentraxin 3 and inflammatory milieu to acute aerobic exercise [J]. Metabolism,2015,64(2) : 323 -9.
10Nakajima T, Kurano M, Hasegawa T, et al. Pentraxin3 and high- sensitive C-reactive protein are independent inflammatory markers released during high-intensity exercise [ J ]. Eur J Appl Physiol , 2010,110(5) : 905 -13.

二级参考文献7

1Azziz R, Carmina E, Dewailly D, et al. The androgen excess and PCOS society criteria for polycystic ovary syndrome: the complete task force report [ J ]. Fertil Steril, 2009,91 ( 2 ) :456 - 88.
2Yildizhan R, Ilham G A, Yildizhan B, et al. Serum retinol-bind- ing protein 4, leptin, and plasma asymmetric dimethylarginine lev- els in obese and nonobese young women with polycystie ovary syn- drome[ J]. Fertil Steril,2011,96 ( 1 ) :246 - 50.
3Webber L J, Stubbs S, Stark J, et al. Formation and early devel- opment of follicles in the polycystic ovary [ J ]. lancet, 2003,362 (9389) :1017 -21.
4Wood J R, Ho C K, Nelson-Degrave V L, et al. The molecular signature of polycystic ovary syndrome (PCOS) theca ceils defined by gene expression profiling [ J ]. J Reprod Immunol, 2004,63 (1) : 51 -60.
5Rice S, Christoforidis N, Gadd C, et al. Impaired insulin-depend- ent glucose metabolism in granulosa-lutein cells from anovulatory women with polyeystic ovaries [ J ]. Hum Reprod, 2005,20 ( 2 ) : 373 -81.
6杜娟,王长江,胡红琳,代芳.多囊卵巢综合征患者空腹血清Ghrelin水平变化及相关因素分析[J].安徽医科大学学报,2013,48(2):178-181. 被引量：8
7宣蓉,胡红琳,方朝晖,代芳,丁璐,杜娟,王长江.多囊卵巢综合征患者血清Orexin A水平变化及意义[J].安徽医科大学学报,2014,49(2):218-221. 被引量：5