摘要
循环microRNA(miRNA)是近年来继组织miRNA之后在血清中发现的非编码小分子RNA,可以稳定存在于血清中。研究表明在胰腺疾病中循环miRNA可出现表达异常,这些异常表达的循环miRNAs可能成为胰腺疾病诊治和评估预后的分子标志物。循环miRNA有望成为胰腺疾病基因治疗的新靶点,本文就循环miRNA在胰腺疾病中的研究进展作一概述。
In recent years, circulating microRNA（miRNA） , another small non-coding RNAs discovered after tissue-specific miRNA, were found in blood plasma with stable existence. Studies have shown that circulating miRNAs will express abnormally in pancreatic disease. The detected aberrantly expressing miRNAs may be used as biomarkers of pancreatic disease in diagnosis, treatment and assessment of prognosis. Circulating miRNAs were expected to become a new target of gene therapy for pancreatic disease. We present a comprehensive review of recent advances of circulating miRNAs as biomarkers in pancreatic disease.
出处
《胃肠病学和肝病学杂志》
CAS
2016年第5期594-596,共3页
Chinese Journal of Gastroenterology and Hepatology
作者简介
第一作者简介：李智德，硕士，研究方向：肝胆胰肿瘤、肝胆外科。E-mail：lizhide6276659@126．com
通讯作者：侯宝华，博士，硕士生导师，主任医师，研究方向：肝胆胰肿瘤的外科综合治疗及胰腺术后早期复发相关性基因的研究。E-mail：hbh1000@126．com
