摘要
目的探讨参菊洗剂的体外抗阴道毛滴虫作用,为临床应用提供参考。方法用肝浸液将参菊洗剂配制成400.00,200.00,100.00,50.00,25.00,12.50,6.25 mg·m L-1培养液,对阴道毛滴虫进行体外培养,分别在2,4,6,8,12,24 h观察阴道毛滴虫的形态和活动状况,计算虫体死亡率,并与相同浓度洁尔阴洗液的体外抗阴道毛滴虫效果进行比较。结果参菊洗剂在体外对临床分离的阴道毛滴虫有抑制和杀灭作用,最低有效浓度为50 mg·m L-1。参菊洗剂各浓度组阴道毛滴虫的死亡率与相同浓度的洁尔阴洗液组比较,差异无统计学意义(P>0.05)。结论参菊洗剂有明显的抗阴道毛滴虫作用。
Objective To investigate the in vitro effect of ShenJu lotion agaisnt Trichomonas vaginalis in order to provide clues for its clinical application. Methods ShenJu lotion was formulated into different concentrations（400.00,200. 00,100.00,50.00,25.00,12.50,6.25 mg·mL^-1 ）with liver extracts.The morphology and movement of Trichomonas vaginalis treated with different concentrations of ShenJu lotion in vitro for 2,4,6,8,12,or 24 h were observed and the mortality was calculated.The effects against Trichomonas vaginalis were compared between Jieeryin lotion and ShenJu lotion at the same concentrations. Results ShenJu lotion could significantly inhibit and kill clinical isolates of Trichomonas vaginalis in vitro and the lowest effective concentration was 50.00 mg·mL^-1 .There was no significant difference in the mortality between ShenJu lotion and Jieeryin lotion（P＆gt;0.05）. Conclusion ShenJu lotion has obvious effects against Trichomonas vaginalis.
出处
《医药导报》
CAS
2016年第5期458-460,共3页
Herald of Medicine
基金
湖北省黄冈市科技计划项目(黄科字[2013]76号)
关键词
参菊洗剂
毛滴虫
阴道
实验
体外
ShenJu lotion
Trichomonas,vagina
Experiment,in vitro
作者简介
张广求（1964-），男，湖北黄梅人，副主任药师，研究方向：医院药学与药物分析。电话：0713—8625312，E-mail：ccnpa@163．com。
