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乌司他丁注射液对急性肺损伤循环内皮祖细胞血管生成能力的影响 被引量:6

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摘要 目的观察乌司他丁注射液对急性肺损伤循环内皮祖细胞血管生成能力的影响。方法成年新西兰大耳白兔(2.5kg^3.0kg)共40只随机分为3组,正常对照组、急性肺损伤组、急性肺损伤组+乌司他丁治疗组分别采用免疫组化法观察肺毛细血管密度,病理评价肺泡炎症。检测体外内皮祖细胞成血管能力。结果 HE染色评估肺泡炎症发现急性肺损伤与乌司他丁治疗组差异有统计学意义(P<0.05);免疫组化观察到乌司他丁治疗组肺毛细血管密度较正常对照组、急性肺损伤组增加(P<0.05);在体外进行细胞培养同样发现乌司他丁治疗组内皮祖细胞的成血管能力较正常对照组、急性肺损伤组提高(P<0.05)。结论乌司他丁注射液能提高急性肺损伤循环内皮祖细胞成血管能力。
出处 《中西医结合心脑血管病杂志》 2016年第6期594-596,共3页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 国家自然科学基金(No.81000244) 上海市自然科学基金(No.12ZR1428400)
作者简介 通讯作者:谢南姿,Email:luobangzhen100@sina.com
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