摘要
目的：探讨血液净化治疗联合济生肾气丸对尿毒症患者蛋白质和能量贮备的影响。方法：124例尿毒症患者随机分为对照组（n=60）和试验组（n=64）。对照组患者给予血液净化治疗,250~300 ml/min,每次4 h,每周3次;试验组患者在对照组治疗的基础上给予济生肾气丸9 g,每日2次。两组疗程均为12个月。观察两组患者治疗前后血红蛋白（Hb）、血尿素氮（BUN）、丙氨酸转氨酶（ALT）、白蛋白（ALB）、血清转铁蛋白（TF）和血浆纤维连接蛋白（FN）,收缩压、舒张压和平均动脉压,体质量指数（BMI）、皮下脂肪厚度和上臂肌肉周径等情况。结果：治疗后,两组患者Hb、TF、FN水平均显著高于治疗前,且试验组高于对照组;ALT、ALB、BUN水平和收缩压、舒张压、平均动脉压均显著低于治疗前,且试验组低于对照组;对照组患者BMI、皮下脂肪厚度和上臂肌肉周径均显著低于治疗前和试验组,差异均有统计学意义（P〈0.05）;试验组患者BMI、皮下脂肪厚度和上臂肌肉周径与治疗前比较,差异均无统计学意义（P〉0.05）。结论：在血液净化治疗的基础上给予济生肾气丸可改善患者体内微环境,提高机体免疫功能,降低炎症引起的代谢加快,改善患者蛋白质和能量贮备,有助于提高其生存质量。
OBJECTIVE： To observe the effects of hemofiltration combined with Jisheng shenqi pill on protein and energy re- serves of uremia patients. METHODS： 124 uremia patients were randomly divided into control group （n= 60） and test group （n = 64）. Control group was given 250-300 ml/min hemofiltration, 4 h for every times, 3 times a week; test group was additionally giv- en 9 g Jisheng shenqi pill, twice a day. The treatment course for both groups was 12 months. Hemoglobin （Hb）, blood urea nitro- gen （BUN）, glutamate aminotransferase （ALT） , albumin （ALB） , serum transferrin （TF）, plasma fibronectin （FN）, systolic blood pressure, diastolic blood pressure, mean arterial pressure; body mass index （BMI）, subcutaneous fat thickness and arm mus- cle circumference in 2 groups before and after treatment were observed. RESULTS： After treatment, Hb, TF and FN levels in 2 groups were significantly higher than before, test group was higher than control group; ALT, ALB, BUN levels, systolic blood pressure, diastolic blood pressure and mean arterial pressure were significantly lower than before, test group was lower than control group; there were significant differences in the BMI, subcutaneous fat thickness and arm muscle circumference between control group and before and test group （P〈0.05）, but there was no significant difference in the BMI, subcutaneous fat thickness and arm muscle circumference in test group before and after treatment（P〉0.05）. CONCLUSIONS： Hemofiltration combined with Jisheng shenqi pill can improve microenvironment in vivo and immtme function, reduce accelerated metabolic induced by inflammation and improve protein and energy reserves to improve life quality of patients.
出处
《中国药房》
CAS
北大核心
2016年第12期1602-1604,共3页
China Pharmacy
作者简介
主治医师。研究方向：膜性肾病的发病机制。E-mail：Leon-510824@163．com
