摘要
目的探讨前列地尔联合还原型谷胱甘肽治疗早中期慢性肾衰竭的临床疗效。方法选取符合慢性肾脏病临床诊断标准的患者40例,随机分配到试验组和对照组,每组20例。试验组按照静脉滴注前列地尔20μg/d,还原性谷胱甘肽注射液1.8 g/d,每个疗程7 d,每月一次。对照组进行常规治疗。观察治疗前和治疗后0.5年、1年、1.5年的24 h尿蛋白、肾小球滤过率（e GFR）及血红蛋白的变化,随访12-36月。结果到第1年末和第1.5年末,与对照组相比,试验组患者血红蛋白明显升高,尿蛋白明显减少,e GFR则下降较慢（P〈0.05）。结论长期、规律地联合应用前列地尔和还原型谷胱甘肽治疗早中期慢性肾衰竭患,能有效延缓肾功能的减退。
Objective To investigate the preventive effects of alprostadil combined with glutathione in the treatment of chronic renal failure. Methods Forty patients with chronic renal failure were randomly assigned to study group（ 20 cases） and control group（ 20 cases）. Patients in the control group only received conventional therapy. Besides conventional treatment,patients in the research group were also treated with alprostadil and glutathione for 7 days in every month. Hemoglobin（ Hb）,Urine protein,hemoglobin,creatinine and estimated glomerular filtration rate（ e GFR） were observed in patients before and after treatment. Results After treatment,compared with the control group,hemoglobin and e GFR in the research group were significantly elevated（ P〈0. 05）,while urine protein and serum creatitine were significantly decreased（ P 0. 05）. Conclusion Long time use of alprostadil and glutathione may effectively delay the deterioration of renal function in patients with chronic renal failure.
出处
《临床和实验医学杂志》
2016年第7期654-656,共3页
Journal of Clinical and Experimental Medicine
关键词
慢性肾衰竭
前列地尔
谷胱甘肽
肾功能
Chronic renal failure
Alprostadil
Glutathione
Renal function
