摘要
【摘要】目的探讨远端导管支气管肺泡灌洗技术治疗特发性肺纤维化（IPF）并感染患者的临床意义。方法IPF并感染患者92例，随机分为远端导管支气管镜灌洗组（A组）32例，普通支气管镜灌洗组（B组）30例，常规治疗组（C组）30例，观察A组与B组的灌洗液回吸收量、细胞总教差异及各组患者治疗前后的降钙素原（PCT）、肺活量水平的变化；治疗1周后观察三组患者致病菌清除率的差异。结果（1）A组的灌洗回吸收量（58±6．85）ml高于B组（51±8．3）ml，A组操作成功率96．9％高于B组80％，差异有统计学意义（P〈0．05）。（2）三组患者治疗1周后的PCT水平较治疗前有明显下降，且A组较B、C组下降更明显（P〈0．01）。三组患者肺活量占预计值百分比（VC％）较治疗前明显上升，且A组VC％较B、C组组上升更明显。（3）治疗1周后A组的致病菌清除率均高于B组、C组（P〈0．05）。结论远端导管支气管肺泡灌洗技术对治疗IPF并感染具有临床应用价值。
Objective To investigate the clinical significance of distal bronchoalveolar lavage with plastic tubing in treatment of idiopathic pulmonary fibrosis （ IPF ） complicated with infection. Methods The 92 IPF co-infection patients were divided into three groups randomly, with 32 cases of distal bronchoalveolar lavage group （ group A ） , 30 cases of common bronchoalveolar lavage group （ group B ） and 30 cases of conventional treatment group （ group C ） . To observe the difference about lavage fluid recycling or total number of cells between group A and group B. To observe the difference about the level of procalcitonin and vital capacity between pretherapy and post-treatment among group A, B and C. To observe the difference about pathogenic bacteria clearance afer one week treatment among group A, B and C. Results （ 1 ） The lavage recycling amount of group A （ 58 ± 6.85 ） was higher than group B （ 51 ± 8.3 ） , success rate of operation of group A （ 96.9% ） was higher than group B （ 80% ） . P〈0.05 . （ 2 ） The level of procalcitonin after one week treatment was lower than that of pretherapy among three groups, and the group A declined more obviously compared with the other two groups （ P〈0.01 ） . Vital capacity of expected value percentage （ VC% ） after one week treatment was higher than that of pretherapy among three groups, and VC% of group A rised more obviously compared with the other two groups. （ 3 ） The rate of pathogenic bacteria clearance in group A after one week treatment was higher than in group B and C （ P〈0.05 ） . Conclusion Distal bronchoalveolar lavage with plastic tubing in treatment of IPF combined with infection has clinical value.
出处
《浙江临床医学》
2016年第5期823-825,共3页
Zhejiang Clinical Medical Journal
