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HIV蛋白酶抑制剂在肿瘤治疗中的作用 被引量：1

The role of HIV protease inhibitors in treatment of neoplasms
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摘要 HIV蛋白酶抑制剂(PIs)是一类抗HIV药物,其广泛应用大大提高了HIV感染者的生存率并延长了其生存期。近来,人们发现PIs具有抗肿瘤活性,这引发了将PIs重新定位为有效肿瘤化疗药物的想法。本文回顾综述了PIs近年来的研究进展以及其在肿瘤治疗中所起的作用,包括已确定的抗肿瘤机制,完成和正在进行的临床试验,为PIs在今后抗肿瘤方向奠定了基础。 HIV protease inhibitors（PIs） are widely used to anti-human immunodeficiency virus, which effectively improves the survival of HIV infected people. Recently, PIs were found to have an activity of anti-neoplasm. So PIs are now being considered as an agent to be used for anti-neoplasm chemotherapy. This artical will review and discuss the current research progress about the mechanism of PIs anti-neoplasm that has been identified, completed and ongoing clinical trials, which will lay the foundation for the future reaserch on PIs anti-neoplasm therapy.
作者 单军奇 张玉林 陈德喜 郭洪亮
机构地区 济南大学山东省医学科学院医学与生命科学学院 山东省肿瘤医院外四科 首都医科大学附属北京佑安医院感染一科 北京市肝病研究所
出处 《中国医药导报》 CAS 2016年第9期51-54,67,共5页 China Medical Herald
基金 国家自然科学基金资助项目(81371399 81571178)
关键词 HIV蛋白酶抑制剂 肿瘤 内质网应激 细胞自噬 HIV protease inhibitor Neoplasm Endoplasmic reticulum stress Autophagy
分类号 R273 [医药卫生—中西医结合]
作者简介 单军奇（1990-），男，济南大学山东省医学科学院医学与生命科学学院2014级外科学专业在读硕士研究生：研究方向：外科学 【通讯作者】郭洪亮（1963-），男，硕士，山东省肿瘤医院外四科科主任，主任医师，硕士生导师；研究方向：胃肠外科。
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参考文献41

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二级参考文献104

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中国医药导报
2016年 第9期

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