摘要
探讨了褐藻羊栖菜4种不同溶剂萃取层的抗抑郁药理活性。采用水煎浸提及超声波辅助提取,制备羊栖菜石油醚、乙酸乙酯、正丁醇和水层提取物。采用常用的抑郁模型"强迫游泳实验"和"悬尾实验",以小鼠强迫游泳和悬尾不动时间作为指标,对4种不同溶剂提取层进行抗抑郁活性研究。实验结果显示,与空白组相比,石油醚、乙酸乙酯和水层均能降低小鼠强迫游泳和小鼠悬尾的不动时间,具有相对的显著性差异。羊栖菜石油醚、乙酸乙酯和水提取物具有抗小鼠实验性抑郁作用。
To explore the antidepressant effect of four different extracted from Sargassum fusiforme. Sargassum fusiforme was extracted by water immersion extraction and ultrasonic wave method. And different extraction were obtained with petroleum ether, ethyl acetate, butanol and water as the solvents resp. To investi-gate the antidepressant activity of four different extraction by the forced swimming test and the tail suspension test, with behavioral despair mice in the immobility time as an indicator in this paper. Petroleum ether, ethyl acetate and water could significantly reduce the immobility time of mice during the forced swimming test and the tail suspension test, compared with that of the control group. Petroleum ether, ethyl acetate and water from Sargassum fusiforme possessed the antidepressant effects.
出处
《浙江海洋学院学报（自然科学版）》
CAS
2015年第6期578-581,592,共5页
Journal of Zhejiang Ocean University(Natural Science Edition)
基金
浙江省大学生新苗人才计划项目(2014R411011)
舟山市医药卫生科技计划攻关项目(2015G01)
关键词
羊栖菜
抗抑郁
绝无行为
不动时间
Sargassum fusiforme
antidepressant effect
behavioral despair
immobility time
作者简介
郭悦（1995-），女，吉林吉林人，研究方向：天然抗抑郁活性成分．
通讯作者：关丽萍，教授．E-mial：glp730@163．com
