摘要
非酒精性脂肪性肝病(NAFLD)是一种非酒精原因所致的以肝细胞脂肪变性为主要特征的临床病理综合征,肝硬化及肝细胞癌是NAFLD的两个最为重要的肝病结局。细胞衰老是细胞脱离正常周期不可逆地丧失增殖能力后进入的一种相对稳定的状态,是细胞生命活动的一种客观规律。研究表明细胞衰老与NAFLD肝纤维化进程及肝细胞癌变的发生发展密切相关,为NAFLD相关肝硬化及肝细胞癌的防治提供了一个新的思路。
Nonalcoholic fatty liver disease（ NAFLD） is a clinicopathological syndrome characterized by fatty degeneration of hepatocytes due to nonalcoholic reasons. Liver cirrhosis and hepatocellular carcinoma are two important outcomes of NAFLD. Cell senescence is a relatively stable state in which cells deviate from the normal cell cycle and experience an irreversible loss of proliferative capacity,which is an objective law in cell life. Research shows that cell senescence is closely associated with the progression of liver fibrosis and the development and progression of hepatocellular carcinoma in NAFLD,and provides a new perspective for the prevention and treatment of liver fibrosis and hepatocellular carcinoma.
出处
《临床肝胆病杂志》
CAS
2016年第3期442-445,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金项目(81570524)
浙江省自然科学基金项目(LY14H070004
LY15H070004)
关键词
脂肪肝
细胞衰老
肝硬化
癌
肝细胞
fatty liver
cell aging
liver cirrhosis
carcinoma,hepatocellular
作者简介
张晶（1988-），女，在读博士，主要从事非酒精性脂肪性肝病与细胞衰老相关方面的研究。
通信作者：施军平，电子信箱：13957121199@126．com。
