摘要
肿瘤坏死因子受体相关蛋白1(tumor necrosis factor receptor-associated protein 1,TRAP1)是热休克蛋白90(Hsp90)家族的主要成员之一,其不仅能够抵御氧化应激所诱导的凋亡,同时在维持线粒体完整性及细胞内稳态方面也发挥着重要作用。研究发现,TRAP1的异常表达与多种肿瘤的发生、发展密切相关。进一步研究表明,TRAP1是肿瘤细胞内能量代谢重新编排的关键调控因素,干预其功能可导致肿瘤细胞的死亡,但却对正常细胞没有影响。这使得TRAP1作为治疗靶点,备受人们关注。该文对TRAP1蛋白的异常表达与肿瘤研究进展进行综述,探讨TRAP1蛋白调控肿瘤进程的相关分子机制,为临床的后续研究和治疗提供参考。
Tumor necrosis factor receptor-associated protein 1( TRAP1),as one of the main members of the heat shock protein90 family,resists oxidative stress-induced apoptosis as well as predominantly maintains the integrity of mitochondria and cellular homeostasis. Abnormal expression of TRAP1 was herein closely related to the onset and progression of a wide variety of tumors. As a key regulatory factor mediating energy metabolism within tumor cells,TRAP1 may be able to kill them by interfering with such metabolism. More importantly,the abnormal expression of TRAP1 played a less important role in normal cells,allowing TRAP1 to be a particularly attractive target as it can be used in tumor treatment or interference. The relationship between abnormal expression of TRAP1 protein and tumor onset was reviewed. Besides, the mechanism by which disordered TRAP1 protein expression induced tumor formation was postulated,which may provide references for future research and clinical treatment.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2016年第4期459-463,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金项目资助(No81173174
81573859)
江苏省自然科学基金(NoBK2012854)
江苏省研究生创新基金(NoCXLX12_0587
KYZZ_0270)
江苏省科技厅项目(NoBY2015008-02)
江苏高校优秀科技创新团队计划
江苏高校品牌专业建设工程资助项目(NoPPZY2015A070)
江苏高校中药学优势学科建设工程资助项目(PAPD)
作者简介
沈培亮（1992-）,男,硕士生,研究方向：活血化瘀中药对肿瘤转移的影响,E-mail：15951938167＠163.com
陆茵（1963-）,女,博士,教授,博士生导师,研究方向：活血化瘀中药对肿瘤转移的影响,通讯作者,E-mail：luyin-green＠126.com
