摘要
目的：观察自拟美白玉容汤联合氨甲环酸口服治疗黄褐斑的临床疗效及研究其机制。方法：选择2012年~2015年我院入院治疗黄褐斑患者60例作为研究对象。以数字法随机分为观察组以及对照组,每组各30例。观察组患者口服自拟美白玉容汤及氨甲环酸0.5g,2次/天,外用4%的氢醌霜,1次/天进行治疗,对照组口服氨甲环酸0.5g,2次/天,外用4%的氢醌霜,1次/天进行治疗。对比观察组两组的治疗效果。结果：治疗前两组患者SDS评分、SAS评分比较无统计学差异,治疗后两组SDS评分和SAS评分均显著降低,观察组SDS评分和SAS评分显著低于对照组（P〈0.05）。两组患者在不同方式治疗前后的生活质量评分比较。结果表明,观察组与对照组患者的生活质量评分在治疗之后,均得到显著缓解。差异具有统计学意义（P〈0.05）。治疗后观察组优良率均明显高于对照组,差异均有统计学意义（P〈0.05）。结论：使用自拟美白玉容汤联合氨甲环酸对黄褐斑患者进行治疗,较单一西药治疗效果显著,可显著提升患者的生活质量,具有较高的临床应用价值。
Objective： To study the clinical effect and mechanism of oral tranexamic acid in treating chloasma. Methods：From 2012 to 2015,we chose 60 cases of patients as the research objects. The digital method was randomly divided into observation group and controlled group,30 cases in each group. The observation group was treated with tranexamic acid 0. 5g,twice a day,topical 4% hydroquinone cream,once a day,orally taken; the controlled group was treated with vitamin C tablets 1. 2g / d,topical 4% hydroquinone cream once a day,orally taken. The effect of the treatment for the two groups was compared. Results：Before treatment,two groups of patients with scores of SDS and SAS score were no significant difference,after treatment,two groups scores of SDS and SAS scores were decreased significantly,and the observation group scores of SDS and SAS score were significantly lower than that of the controlled group（ P〈0. 05）. The quality of life of the two groups of patients before and after treatment in different ways compared the quality of life. The results showed that the quality of life of the observation group and the controlled group were significantly relieved after treatment. The difference was statistically significant（ P 0. 05）. The effect of the observation group was excellent and good rate were significantly higher than the controlled group,the differences were statistically significant（ P〈0. 05）. Conclusion： Tranexamic acid for the treatment of patients with melasma,can effectively play its effectiveness,and improve the quality of life of the patients,play a certain aesthetic effect.
出处
《四川中医》
2016年第3期161-163,共3页
Journal of Sichuan of Traditional Chinese Medicine
关键词
黄褐斑
氨甲环酸
临床疗效
美白玉容汤
Chloasma
Tranexamic acid
Clinical effect
Meibai Yurong Decoction
