摘要
目的:探讨补阳还五方不同时间给药治疗脑缺血再灌注导致血管性痴呆小鼠的行为学变化。方法:利用双侧颈动脉反复结扎再通的方法复制缺血再灌注血管性痴呆小鼠模型,造模即刻给中药补阳还五方和造模后3天给该药,治疗10天后观察两组痴呆小鼠行为学的不同。结果:补阳还五方即刻治疗组跳台实验潜伏期延长,错误次数明显减少,说明即刻治疗组小鼠与3天后治疗组小鼠的记忆成绩相比差异有显著性。结论:中药补阳还五方即刻治疗血管性痴呆的疗效优于3天后治疗,所以血管性痴呆一旦确诊应采取尽快治疗的原则。
Objective： to explore praxiological changes of reperfusion-induced VD rats by administering Buyang Huanwu Formula at different time. Methods： ligating the bilateral carotid arteries repeatedly before recanalizing to make ischemia reperfusion-induced VD rat models,Buyang Huanwu Formula was administered instantly and once again after 3 days. Praxiology changes of VD rats were observed ten days later. Results： Instant treatment group had prolonged latent phase with fewer errors in jumping stand experiment,which showed that the difference of memory performance was of significance compared to that of 3-days-later treatment group. Conclusion： the curative effect of instant administration is superior to the administration 3 days later,and therefore VD should be treated as soon as possible once final diagnosis is made.
出处
《河北中医药学报》
2016年第1期5-7,共3页
Journal of Hebei Traditional Chinese Medicine and Pharmacology
基金
河北省中医药管理局科研计划资助项目:No.2014199
关键词
补阳还五方
血管性痴呆
不同时间
行为学
缺血再灌注
Buyang Huanwu Formula
VD（vascular dementia）
at different time
praxiology
ischemia reperfusion
