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慢性心力衰竭利尿剂抵抗患者应用托伐普坦的疗效分析 被引量:16

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摘要 目的观察托伐普坦治疗慢性心力衰竭伴低钠血症及利尿剂抵抗的疗效,探讨其作用机制。方法收集慢性心力衰竭伴低钠血症及利尿剂抵抗患者60例,随机分为试验组和对照组各30例,试验组给予托伐普坦治疗,对照组给予呋塞米治疗。用药7d后,观察2组Na+、K+、尿量、血肌酐、6min步行试验距离、血浆氨基末端脑钠肽前体(N-terminal fragment of pro BNP,Pro-BNP)等指标的变化。结果治疗后对照组轻度、中度和重度低钠血症患者血钠浓度无明显变化,而试验组治疗后轻度、中度和重度低钠血症患者血钠浓度较治疗前明显升高(P<0.05),治疗后2组差异有统计学意义(P<0.05或<0.01);治疗后2组NYHA分级均有降低(P<0.05或<0.01),但试验组降低更多,治疗后2组差异有统计学意义(P<0.01);治疗后试验组Na+、K+、尿量、6min步行试验距离均较对照组明显增加,血肌酐和Pro-BNP均较对照组明显降低(P<0.01)。结论精氨酸加压素受体拮抗剂托伐普坦治疗慢性心力衰竭伴低钠血症及利尿剂抵抗疗效良好,且早期用药可以达到更好的临床效果。
作者 刘梅臣 李帆
出处 《河北医科大学学报》 CAS 2016年第3期313-316,共4页 Journal of Hebei Medical University
作者简介 刘梅臣(1975-),舅,广东蕉岭人,广东省蕉岭县人民医院主治医师,从事内科疾病诊治研究。
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