摘要
探讨固肾安胎丸联用黄体酮治疗先兆流产的临床疗效,为临床早期干预先兆流产提供思路和借鉴。选择收集的先兆流产患者共112例,随机分成对照组（n=56）和观察组（n=56）,对照组患者常规给予黄体酮针,观察组在对照组基础上再口服固肾安胎丸,2组均采用药物治疗2周,并于治疗前及治疗后1-2周抽取静脉血5 m L,测定血清β-HCG,P,E2和CA125水平,比较治疗后2组间的差异。观察组的有效率为91.9%,对照组为79%,2组的有效率比较,差异有统计学意义（P〈0.05）。治疗2周后,观察组血清P和E2水平均较治疗前明显上升,血清CA125水平显著下降（P〈0.05）,与同期对照组的这些指标比较,差异有统计学意义（P〈0.05）;治疗后2组血清β-HCG水平较治疗前均显著上升（P〈0.05）,但2组该水平比较,差异无统计学意义。固肾安胎丸联用黄体酮治疗先兆流产具有较好的临床疗效,可显著提升血清β-HCG,P,E2水平,降低血清CA125水平,增加保胎的有效率,值得临床推广应用。
To investigate the clinical effect of Gushen Antai pills and progesterone in the treatment of threatened abortion,in order to provide references for early clinical intervention with threatened abortion. The 112 cases of patients with threatened abortion were randomly divided into the control group and the observation group. 56 cases in each group. Patients in the control group was injected with progesterone,the observation group was treated with Gushen Antai pills in addition to the therapy of the control group. Both groups were treated by drugs for two weeks. Their venous bloods（5 m L） were collected before treatment and in 1,2 weeks after treatment to determine serum levels of β-HCG,P,E2 and CA125. The differences between the two groups after treatment were compared. The total effective rate of the control group and the observation group were 79% and 91. 9% respectively,with a statistically significant difference between the two groups（ P〈 0. 05）. Two weeks after the treatment,the serum levels of P and E2 in the observation group were significantly higher than before treatment,but the serum CA125 levels decreased significantly after treatment（ P〈 0. 05）. These indicators showed statistically significant difference compared with that of the control group（ P〈 0. 05）. After treatment,the serum β-HCG levels of the two groups were significantly higher than before treatment（ P〈 0. 05）,but there was no statistically significant difference between the two groups. Gushen Antai pills and progesterone had a better clinical curative effect in treatment threatened abortion,which could significantly raise serum β-HCG,P and E2,reduce serum CA125 and increase the tocolysis efficiency,and so it was worth promoted in clinic.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第2期321-325,共5页
China Journal of Chinese Materia Medica
基金
山东省医药卫生科研基金项目(2013134)
作者简介
[通信作者]陈波，副主任医师，主要从事妇产科研究，E—mail：779229498@qq．com
