先天性心脏病术后急性肾损伤患儿尿液NGAL、血清CysC水平变化及意义被引量：14

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摘要目的探讨先天性心脏病（CHD）术后急性肾损伤（AKI）患儿尿液中性粒细胞明胶酶相关脂质蛋白（NGAL）和血清胱抑素C（Cys C）水平变化及意义。方法选择162例行心脏手术的CHD患儿,术后次日发生AKI44例（AKI组）,未发生AKI 118例（非AKI组）。采用ELISA法检测两组术前及术后次日尿液NGAL和血清Cys C水平,并分析其与AKI的关系。结果 AKI组术后尿液NGAL、血清Cys C水平均高于术前及非AKI组（P均〈0.05）;非AKI组手术前后尿液NGAL、血清Cys C水平比较差异均无统计学意义（P均〉0.05）。相关分析显示,术后尿NGAL（OR=2.314,95%CI为0.508~7.652）、血清Cys C（OR=1.401,95%CI为0.322~6.014）水平升高是发生AKI的独立危险因素（P均〈0.01）。结论 CHD患儿术后AKI发生率较高;AKI发生可能与术后尿液NGAL、血清Cys C水平升高有关。

作者谢雪梅魏从真赵小洁高灵灵耿玉兰李小兵

机构地区榆林市中医医院河北医科大学第一医院

出处《山东医药》 CAS 北大核心 2016年第8期73-74,共2页 Shandong Medical Journal

基金河北省医学科学研究重点课题计划(20110317)

关键词急性肾损伤中性粒细胞明胶酶相关脂质蛋白胱抑素C 心脏手术

分类号 R619 [医药卫生—外科学]

作者简介通信作者：赵小洁（E-mail：740545025@qq．com）。

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