摘要
目的分析并探讨不同阶段糖尿病肾病患者血清高敏C反应蛋白、C反应蛋白水平的变化特点。方法选取2005年3月至2015年4月在广西壮族自治区职业病防治研究院接受治疗的2型糖尿病患者100例,根据尿蛋白/尿肌酐结果将100例患者分为单纯型糖尿病组(<30 mg/g,n=28)和糖尿病肾病组(≥30 mg/g,n=72),选取同期健康体检患者30例为健康对照组。使用免疫荧光法检测高敏C反应蛋白和C反应蛋白水平。结果单纯性糖尿病组高敏C反应蛋白水平为(1.53±0.47)mg/L,C反应蛋白水平为(7.23±1.13)mg/L。糖尿病肾病组高敏C反应蛋白水平为(2.14±0.63)mg/L,C反应蛋白水平为(19.35±4.12)mg/L。健康对照组高敏C反应蛋白水平为(0.71±0.21)mg/L,C反应蛋白水平为(1.91±0.34)mg/L。糖尿病肾病组高敏C反应蛋白和C反应蛋白水平显著高于单纯型糖尿病组、健康对照组,差异有统计学意义(P<0.05)。随着蛋白尿水平的提高,血清高敏C反应蛋白水平和C反应蛋白水平也逐渐升高(P<0.05)。小量蛋白尿组高敏C反应蛋白为(1.70±0.31)mg/L,C反应蛋白为(12.53±1.24)mg/L。中量蛋白尿组高敏C反应蛋白为(2.39±0.32)mg/L,C反应蛋白为(22.36±3.11)mg/L。大量蛋白尿组高敏C反应蛋白为(2.91±0.47)mg/L,C反应蛋白为(32.93±4.35)mg/L。大量蛋白尿组血清高敏C反应蛋白水平和C反应蛋白水平高于小量蛋白尿组、中量蛋白尿组(P<0.05);中量蛋白尿组显著高于小量蛋白尿组(P<0.05)。结论炎性因子参与了糖尿病肾病致病过程,为糖尿病肾病发生机制提供了理论基础。
Objective To analyze and discuss the changing characteristics of serum high-sensitivity C-reactive protein （hs-CRP）, C-reactive protein （CRP） levels in the different stages of diabetic nephropathy. Methods Total of 100 patients with type 2 diabetes were selected in Guangxi Institute of Occupational Disease Prevention and Control from Mar. 2005 to Apr. 2015 ,according to the urine protein/urine creatinine test results, the 100 patients were divided into simple diabetes group （ 〈 30 mg/g, n = 28 ） and diabetic nephrepathy group（≥30 mg/g,n =72） ,and 30 healthy volunteers during the same period were included as a control group, hs-CRP and CRP levels were detected by immunofluorescence method. Results hs-CRP level of Simple diabetes group swas （ 1.53 ±0. 47） mg/L,CRP level was （7.23 ± 1.13） mg/L;hs-CRP level of diabetic nephrepathy group was （2. 14 ± 0. 63 ） mg/L, CRP level was （ 19. 35 ± 4. 12） mg/L; hs-CRP level of the healthy control group was （0.71 ± 0.21 ） mg/L, CRP level was （1.91 ± 0.34 ） mg/L. The hs-CRP and CRP level of diabetic nephrepathy group were significantly higher than the diabetic group and healthy control group, the differences were statistically significant（ P 〈 0. 05 ）. With the increase of the level of preteinuria, serum hs-CRP and CRP levels also gradually increased （ P 〈 0.05 ）. hs-CRP level of small amount preteinu- ria group was （ 1.70 ± 0. 31 ） rag/L, CRP level was （ 12. 53 ± 1.24） mg/L; hs-CRP level of medium amount proteinuria group was （2. 39 ±0. 32） mg/L,CRP level was （22. 36 ±3. 11 ） mg/L;hs-CRP level of Macrealbuminuria group was （2.91 ± 0. 47 ） mg/L, CRP level was （ 32.93 ± 4. 35 ） mg/L. The hs-CRP and CRP level of macroalbuminuria group were higher than the small amount preteinuria group and medium amount preteinuria group（ P 〈 0. 05 ） ;and the medium amount proteinuria group was higher than the small amount preteinuria group （ P 〈 0. 05 ）. Conclusion The inflammatory cytokines are involved in the pathogenesis of diabetic osteopathy, providing a theoretical basis for diabetic nephrepathy mechanisms.
出处
《医学综述》
2016年第5期1020-1022,共3页
Medical Recapitulate
关键词
糖尿病肾病
高敏C反应蛋白
C反应蛋白
Diabetic nephropathy
High-sensitivity C-reactive protein
C-reactive protein
