摘要
目的观察右美托咪定对肝切除缺血再灌注损伤氧化应激的影响。方法选择2013年4月-2015年6月行肝切除术的患者86例,随机分为A组（右旋美托咪定组）和B组（对照组）,每组43例。A组于麻醉诱导前10min,泵注1μg/kg右美托咪定,时间15min,后泵注右美托咪定0.4μg/（kg·h）维持,B组术前、术中泵注生理盐水,在麻醉后（T1）、关腹前（T2）、手术结束后1h（T3）、手术结束后4h（T4）、手术结束后8h（T5）检测超氧化物歧化酶（SOD）、丙二醛（MDA）、白细胞介素-8（IL-8）和人肿瘤坏死因子α（TNF-α）。结果右旋美托咪定组T3-T5时间点SOD含量高于对照组,MDA、IL-8、TNF-α含量在T4-T5时间点低于对照组,差异有统计学意义（P〈0.05）。结论右美托咪定应用于肝切除手术,能减轻缺血再灌注损伤导致的氧化应激反应以及炎性因子释放。
Objective To observe effect of dexmedetomidine on oxidative stress caused by hepatic ischemiareperfusion injury induced. Methods 86 patients receiving hepatectomy from April 2013 to June 2015 were selected and they were allocated to group A（the dexmedetomidine group）and group B（the control group）,with 43 in each.A group was received 1μg/kg infusion pump of dexmedetomidine for 15 minutes at 10 minutes before anesthesia induction.And it was received 0.4μg/（kg·h） infusion pump of dexmedetomidine for maintenance.Group B was received infusion pump of normal saline before and after operation.Superoxide dismutase（SOD）,malondialdehyrde（MDA）,inter leukin-8（IL-8）and human tumor necrosis factorα（TNF-α）after anesthesia（T1）,before closing abdomen（T2）,1h after operation（T3）,4h after operation（T4）and 8h after operation（T5）were detected. Results SOD content at T3-T5 of the dexmedetomidine group was higher than that of the control group.Contents of MDA,IL-8 and TNF-α at T4-T5 were lower than those of the control group.The difference was statistically significant（P〈 0.05）. Conclusion Application of dexmedetomidine in hepatectomy can reduce oxidative stress reactions and release of inflammatory factors caused by ischemia-reperfusion injury.
出处
《中国医药科学》
2015年第24期12-15,共4页
China Medicine And Pharmacy
基金
广东省科技计划项目(2011B031800061)
关键词
右美托咪定
肝切除
缺血再灌注
损伤
Dexmedetomidine
Hepatectomy
Ischemia-reperfusion
Injury
作者简介
通讯作者
