摘要
目的分析2型糖尿病合并脑梗死患者颈动脉粥样硬化发生情况及其临床意义。方法选取2012年12月—2015年6月佛山市第一人民医院诊治的2型糖尿病患者180例,按照是否合并脑梗死分为未合并脑梗死者86例(对照组)和合并脑梗死者94例(研究组)。两组患者均接受颈动脉超声检查及生化指标检测,比较两组患者颈动脉粥样硬化检出率、左侧颈动脉内膜-中层厚度(IMT)、右侧颈动脉IMT及超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、s CD36、salusin-α水平。结果研究组患者颈动脉粥样硬化检出率为88.3%,高于对照组的51.2%(χ2=29.812,P<0.01);研究组患者左侧颈动脉和右侧颈动脉IMT均高于对照组(P<0.05);研究组患者hs-CRP、Hcy、LDL及salusin-α水平高于对照组,HDL和s CD36水平低于对照组(P<0.05)。结论 2型糖尿病合并脑梗死患者颈动脉粥样硬化发生率较高,临床应尽早干预,尽可能稳定颈动脉粥样硬化斑块、延缓斑块形成。
Objective To analyze the occurrence dynamics and clinical significances of carotid artery atherosclerosis in type 2 diabetes mellitus patients complicated with cerebral infarction. Methods A total of 180 patients with type 2 diabetes mellitus were selected in the First People＇s Hospital of Foshan from December 2012 to June 2015, and they were divided into A group （complicated with cerebral infarction, n = 94 ） and B group （did not complicated with cerebral infarction, n = 86 ） according to the occurrence of cerebral infarction. Patients of both groups received carotid artery ultrasonography and biochemical index detection, detection rate of carotid artery atherosclerosis, left CIMT, right CIMT, hs-CRP, Hcy, LDL, HDL, sCD36 and salusin-α were compared between the two groups. Results The detection rate of carotid artery atherosclerosis of A group was 88.3%, was statistically significantly higher than that of B group of 51.2% （ X^2 = 29. 812, P 〈 0.01 ） ; left CIMT and right CIMT of A group were statistically significantly higher than those of B group （P 〈0. 05） ; hs-CRP, Hcy, LDL and salusin-ot of A group were statistically significantly higher than those of B group, while HDL and sCD36 of A group were statistically significantly lower than those of B group （ P 〈 0. 05）. Conclusion The detection rate of carotid artery atherosclerosis of type 2 diabetes mellitus patients complicated with cerebral infarction is relatively high, clinicians should intervene as soon as possible, to keep ,the stability of carotid artery atherosclerostic plaques and delay the plaque formation.
出处
《实用心脑肺血管病杂志》
2015年第12期52-54,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
糖尿病
2型
脑梗死
颈动脉
动脉粥样硬化
Diabetes mellitus, type 2
Brain infarction
Carotid arterie
Atherosclerosis
