摘要
目的研究他汀类药物在急性冠状动脉综合征介入治疗前的应用价值。方法将我院2009年2月~2014年5月收治的134例急性冠状动脉综合征患者抽签随机分为观察组与对照组,在共同强化治疗的基础上,术前给予观察组他汀类药物治疗,比较两组患者血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）及C反应蛋白（CRP）的水平。结果术后1、3、7 d,观察组的CRP分别为（11.30±4.21）、（10.03±2.16）、（8.67±3.97）mg/L,显著低于对照组的（13.86±2.03）、（12.33±4.26）、（11.87±1.67）mg/L（P〈0.05）;两组患者CRP值于术后1 d上升后均呈下降趋势,且观察组降幅明显,术后7 d基本恢复至术前水平。治疗后观察组TC、TG、LDL分别为（2.41±0.34）、（1.56±0.47）、（2.33±0.64）mmol/L,显著低于对照组的（3.45±0.61）、（2.60±0.43）、（3.42±0.31）mmol/L（P〈0.05）,观察组HDL水平为（1.30±0.47）mmol/L,高于对照组的（0.76±0.52）mmol/L（P〈0.05）。结论他汀类药物应用于急性冠状动脉综合征介入术前效果显著,具有较高的安全性和临床应用价值。
Objective To explore the application value of statins as interventions in acute coronary syndrome before treatment. Methods 134 patients with acute coronary syndrome who treated in our hospital from February 2009 to May2014 were randomly divided into observation group and control group.On the basis of common intensive treatment,statins for the treatment before surgery were provided in the observation group.The changes of serum total cholesterol（TC）,triglycerides（TG）,low density lipoprotein（LDL）,high density lipoprotein（HDL） and C-reactive protein（CRP） levels were compared between two groups. Results In the observation group,1,3,and 7 d after surgeries,the level of CRP was（11.30±4.21）,（10.03±2.16）, and（8.67±3.97） mg/L respectively,which was greatly decreased in comparison with that in the control group,（13.86±2.03）,（12.33±4.26）,and（11.87±1.67） mg/L respectively（P〈0.05）.Although the values of CRP in the two groups was in declined tendencies after transient increase one day after surgeries,the decreasing amplitude in the observation group was obvious and was returned to preoperative level 7 d after surgeries.After therapy,the levels of TC,TG,and LDL was respectively（2.41±0.34）,（1.56±0.47）,and（2.33±0.64）mmol/L in the observation group,lower than（3.45±0.61）,（2.60±0.43）,and（3.42±0.31） mmol/L in the control group respectively（P〈0.05）.The value of HDL in the observation group was（1.30±0.47） mmol/L,higher than（0.76±0.52） mmol/L in the control group（P〈0.05）. Conclusion Application of statins as preoperative interventions in ACS can obtain a remarkable effect with higher safety and clinical value.
出处
《中国当代医药》
2016年第4期147-149,共3页
China Modern Medicine
