摘要
目的评价可降解镁合金覆膜支架治疗兔颈总动脉侧壁型动脉瘤的可行性。方法 20只新西兰大白兔饲养1周后采用间断式外翻缝合法将右侧颈总动脉与静脉囊吻合,构建20枚颈总动脉侧壁型动脉瘤。72 h内分别实施可降解镁合金覆膜支架植入术和Willis覆膜支架植入术。术前、术后即刻、术后3、6、12个月作DSA造影检查,对比动脉瘤闭塞、内漏、血管痉挛、血管损伤、血栓事件、血管闭塞和狭窄等情况。结果可降解镁合金覆膜支架和Willis覆膜支架各植入10枚,技术成功率为100%。支架植入术后即刻造影显示所有动脉瘤腔完全闭塞,载瘤动脉通畅,可降解镁合金覆膜支架组血管痉挛3例,Willis覆膜支架组血管痉挛1例;术后3、6、12个月复查造影显示动脉瘤完全消失,载瘤动脉通畅。结论可降解镁合金覆膜支架治疗兔颈总动脉侧壁型动脉瘤是可行的。
Objective To evaluate the feasibility of using biodegradable magnesium alloy covered stent to treat common carotid artery （CCA） lateral wall aneurysm in experimental rabbits. Methods A total of 20 New Zealand white rabbits were fed for one week. A venous pouch of one em size was sheared from the external jugular vein, then by using intermittent suture methodthe right CCA was anastomosed with the venous pouch to create a lateral wall aneurysm of CCA in all rabbits. Within 72 hours after the anastomosis was performed the implantation of biodegradable magnesium alloy covered stem （n=10） and the implantation of Willis covered stent （n=10） were separately carried out. DSA examination was employed before and immediately after the procedure, as well as at 3, 6 and 12 months after the procedure to evaluate the condition of aneurysm occlusion, internal leakage, vasospasm, vascular injury, thrombosis, vascular occlusion or stenosis, etc. The results were compared between the biodegradable magnesium alloy covered stent group and Willis covered stent group. Results Ten biodegradable magnesium alloy eoveredstents and 10 Willis covered stents were separately implanted, and the technical success rate of stent implantation was 100%. Angiography performed immediately after stent implantation showed that in all rabbits the aneurysm was completely occluded and the CAA remained patent. Vascular spasm was observed in 3 rabbits of biodegradable magnesium alloy coveredstent group and in one rabbit of Willis covered stent group. Angiography performed at 3, 6 and 12 months after stent implantation revealed that the aneurysm completely disappeared in all rabbits, while the CAA still remained patent. Conclusionln treating CCA lateral wallaneurysm of experimentalrabbits, the using of biodegradable magnesium alloy covered stentis practically feasible.
出处
《介入放射学杂志》
CSCD
北大核心
2016年第2期151-154,共4页
Journal of Interventional Radiology
基金
国家自然科学基金(81201199)
作者简介
通信作者：程英升E-mail：cjr．chengysh@vip．163．com.
