摘要
目的:了解宜昌市不同年龄段女性人乳头瘤病毒的感染情况,促进人乳头瘤病毒检测更好地应用于宫颈癌筛查。方法:通过微点样基因芯片法对2014年1月1日～2014年12月31日在我院进行人乳头瘤病毒检测的样本进行分析。结果:4 025例标本HPV感染阳性构成比为35.51%,HPV高危型阳性构成比为28.80%,HPV低危型阳性构成比为12.14%,不同年龄段人群感染构成比具有统计学差异。HPV感染主要为单一型别的感染,高危型别主要为16型的感染,低危型别主要为54型的感染。结论:不同年龄段人群HPV感染具有差异性,可根据不同年龄段HPV感染的特点进行宫颈癌筛查。
Objective:To investigate the infection status of human papillomavirus(HPV)in the women of different ages in Yi Chang city,and to promote the application of HPV testing for the cervical cancer screening.Methods:Using gene chip technology,we analysed the HPV infection situation of the patients of our hospital during January 1 th of 2014 to December 31th of 2014.Results:In the total of 4 025 patients,the infection constituent ratio of HPV was 35.51%,including 28.80%for the high-risk HPV and 12.14%for the low-risk HPV infection.The infection constituent ratio showed statistically difference in the different age groups.In the HPV positive patients,single type infection was predominant,in which HPV16 and HPV54 were the the most common types for the high-risk and low-risk HPV infective groups separately.Conclusion:We may take the different strategy for the cervical cancer screening in the varient age groups considering the difference of HPV infection status,which were showed in this study.
作者
王清
唐立华
胡余昌
陈路
郎博娟
刘旭
张丁
Wang Qing;Tang Lihua;Hu Yuchang;Chen Lu;Lang Bojuan;Liu Xu;Zhang Ding(Department of Pathology,Yichang Central People’s Hospital,The First College of Clinical Medical Science,China Three Gorges University&Institute of Pathology,China Three Gorges University,Yichang 443003,China;Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,Yichang 443003,China)
出处
《巴楚医学》
2018年第1期79-82,114,共5页
Bachu Medical Journal
基金
肿瘤微环境与免疫治疗湖北省重点实验室开放基金项目(No:2016KZL10)
关键词
人乳头瘤病毒
宫颈癌
实验室检测
human papillomavirus(HPV)
cervical cancer
laboratory testing
作者简介
王清,女,硕士,主管技师,主要从事分子病理方面研究。E-mail:ctguwangqing@163.com;通讯作者:唐立华,男,博士,副主任医师,主要从事肿瘤病理方面研究。E-mail:tangball@sina.com
