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美多巴单用及联合普拉克索治疗帕金森病的疗效和安全性比较 被引量:60

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摘要 目的探讨美多巴单用及联合普拉克索治疗帕金森病(PD)的疗效和安全性。方法选取100例该院帕金森病专病门诊及住院PD患者,随机分为观察组和对照组各50例。对照组给予美多巴,观察组给予多巴联合普拉克索,连续治疗8 w。比较两组汉密顿抑郁量表(HAMD)评分、Hoehn-Yahr分期、临床疗效及副作用量表(TESS)评分。结果治疗后1~8 w,观察组HAMD评分显著高于对照组(P〈0.05)。治疗8 w后,观察组Hoehn-Yahr分期显著低于对照组(P〈0.05)。观察组治疗有效率显著高于对照组(P〈0.05)。观察组TESS评分显著低于对照组(P〈0.05)。结论美多巴联合普拉克索治疗PD可有效提高临床疗效,减少不良反应,其效果优于单纯美多巴治疗。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第2期424-425,共2页 Chinese Journal of Gerontology
基金 吉林省科技厅青年基金项目(20130522026JH)
作者简介 姜立刚(1978-),男,博士,博士后,副主任医师,副教授,硕士生导师,主要从事帕金森病基础与临床研究。 通讯作者:李威(1959-),女,主任医师,教授,硕士生导师,主要从事帕金森病基础与临床研究。
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参考文献16

  • 1Litvan I,Goldman JG,Trster AI,et al.Diagnostic criteria for mild cognitive impairment in Parkinson's disease:Movement Disorder Society Task Force guidelines[J].Movement Disorders,2012;27(3):349-56.
  • 2Lill CM,Roehr JT,Mc Queen MB,et al.Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics:The PDGene database[J].PLo S Genetics,2012;8(3):e1002548.
  • 3Muller T,Hellwig R,Muhlack S.Levodopa induces synthesis of nerve growth factor and growth hormone in patients with Parkinson disease[J].Clin Neuropharmacol,2011;34(3):101-3.
  • 4Schapira AH,Mc Dermott MP,Barone P,et al.Pramipexole in patients with early Parkinson's disease(PROUD):a randomised delayed-start trial[J].Lancet Neurol,2013;12(8):747-55.
  • 5Broen MP,Moonen AJ,Kuijf ML,et al.Factor analysis of the Hamilton Depression Rating Scale in Parkinson's disease[J].Parkinsonism Relat Dis,2015;21(2):142-6.
  • 6Kataoka H,Tanaka N,Saeki K,et al.Low frontal assessment battery score as a risk factor for falling in patients with Hoehn-Yahr StageⅢParkinson's disease:a 2-year prospective study[J].European Neurol,2013;71(3-4):187-92.
  • 7吕荣祥.美多巴联合普拉克索治疗帕金森病的有效性及安全性研究[J].中国生化药物杂志,2014,34(3):153-155. 被引量:46
  • 8沈国柱.多巴胺受体激动剂普拉克索治疗帕金森氏病的临床疗效分析与安全性评价[J].海峡药学,2012,24(1):162-163. 被引量:40
  • 9Hauser RA,Schapira AH,Barone P,et al.Long-term safety and sustained efficacy of extended-release pramipexole in early and advanced Parkinson's disease[J].European J Neurol,2014;21(5):736-43.
  • 10刘国敏.单用美多巴及与多巴胺受体激动剂合用治疗帕金森病的疗效和安全性研究[J].中国医学工程,2013,21(8):56-56. 被引量:7

二级参考文献60

  • 1温洪波,张振馨,罗毅,陈生弟,蒋雨平,张小英,孙相如,王新德,姚晨.普拉克索治疗帕金森病的多中心、随机、双盲、溴隐亭对照临床疗效和安全性研究[J].中华神经科杂志,2006,39(9):604-608. 被引量:63
  • 2武力勇,贾建平.普拉克索的临床应用及安全性[J].药物不良反应杂志,2007,9(2):77-80. 被引量:20
  • 3Schapira AH.Dopamine agonists and neuro protection in Parkinson's.disease[J].EurJ Neurol,2002,9(Supp 13):7-14.
  • 4Kondo T.Initial therapy for Parkinson's disease:levodopavs dopamine receptor agonists[J].J Neurol,2002,249 (Supp 12):Ⅱ25-Ⅱ29.
  • 5Moler JC,Oertel WH,Koster J,et al.Long-term efficacy and safety of pramipexole in advanced Parkinson's disease:results from a European multicenter trial[J].Mov Disurd,2005,20(5):602-610.
  • 6Mizuno Y,Yanagisawa N,Kuno S,et al.Randomized,doubleblind study ofp ramipexole with placebo and bormocriptine in advanced Parkinson's disease[J].Mov Disord,2003,18(11):1149-1156.
  • 7Clarke CE,Guttman M.Levodopa agonist monotherapy in Parkinson's disense[J].Lancet,2002,360(9347):1767-1769.
  • 8Gu M,lravani MM,Cooper JM,et al.Pramipexole protects against Apoptotic cell death by non-dopaminergic mechanisms[J].J Neuorchem,2004,91(5):1075-1081.
  • 9AsanumaM,MiyazakiI,Diaz-CorralesFJ,et al.Pramipexole hasAmeliorating effects on levodopa-induced abnormal dopamine turnover in parkinsonian striatum and quenching effects on dopaminesemquinone generated in vitro[J].Neurol Res,2005,27(5):533-539
  • 10Pahwa R,Factor SA,Lyons KE,et al.Practice parameter:,treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review)report of the quality standards subcommittee of the American academy of neurology[J].Neurology,2006,66(7):983-995.

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