摘要
微RNA(miRNAs)是一组高度保守的内源性非编码小RNAs,在转录后水平调控基因的表达,参与炎症、发育、凋亡、肿瘤等多种生理病理过程。miR-34a是一个典型的多功能miRNA,其异常表达影响着肿瘤的发生、发展。消化道肿瘤是一种高发病率和病死率的疾病,严重地威胁着人类的生命健康。miR-34a通过多条信号通路在胃癌、结直肠癌、肝癌以及胰腺癌等消化道肿瘤的发生、诊断、治疗及预后中发挥着重要的作用。
MicroRNAs（ miRNAs） are a class of highly conserved endogenous small non-coding RNAs,which regulate gene expression at the post-transcriptional level and involve in various physiological and pathological processes,including inflammation,growth,apoptosis and tumor. MiR-34 a is a typical multifunctional miRNA,and the abnormal expression of miR-34 a is closely related to the occurrence and development of tumors. Gastrointestinal tumors are a group of diseases with high morbidity and mortality that serious threat human life and health. MiR-34 a plays a key role in pathogenesis,diagnosis,therapy and prognosis of the gastrointestinal tumors,such as gastric,colorectal,liver and pancreatic cancer,through multiple signaling pathways.
出处
《医学综述》
2016年第1期83-87,共5页
Medical Recapitulate
基金
黑龙江省卫生厅科研基金(2013044)
作者简介
在读研究生
通讯作者E—mail：dqwujm@163．com
