摘要
目的探讨采用心脏专用Argus软件评估乳腺癌新辅助化疗(NAC)疗效的可行性。方法收集经病理学确诊的乳腺浸润性导管癌患者23例(1例为双侧病变,共计24侧),分别于化疗前及4次化疗后接受3.0T动态增强磁共振扫描(DCE-MRI)。将DCE-MRI第2期图像经3D软件重建后载入心脏专用Argus浏览器,由2名放射科医师分别盲法绘制并计算肿瘤体积,最终结果取二者的平均值。采用配对t检验比较NAC前后肿块体积差异。结果化疗前24侧乳腺癌肿块体积为3.9~42.1cm^3,平均(13.71±9.47)cm^3,4次化疗后体积为0.3~29.4cm^3,平均(4.81±4.15)cm^3,二者差异有统计学意义(t=6.36,P<0.01)。结论 Argus心脏专用软件包可方便、准确地测量乳腺癌肿块体积、用于评估乳腺癌NAC化疗疗效。
Objective To explore the feasibility of Argus software on evaluation of neoadjuvant chemotherapy（NAC）in patients with breast cancer.Methods Twenty-three patients with histopathologically proven invasive ductal carcinoma（twenty-four sides totally,one case with bilateral breast cancer）,and underwent NAC were collected.All patients underwent 3.0 Tdynamic contrast enhanced magnetic resonance imaging（DCE-MRI）before and after 4 cycles of chemotherapy,and the images in second phase were transported to Argus software.The volume of tumor before and after 4 cycles of chemotherapy were measured by two experience radiologists blindly,the final results were averaged.The tumor volumes measured before and after NAC were compared with paired samples t test.Results Before and after 4 cycles of chemotherapy,the averaged volume of 24 sides breast tumor was（13.71±9.47）cm^3（[3.9—42.1]cm^3） and （4.81±4.15）cm^3（[0.3—29.4]cm^3）,respectively,and the difference was statistically significant（t=6.36,P0.01）.Conclusion It is convenient and accurate of breast tumors volume measured using Argus software.It can be used to assess the efficacy of NAC in patients with breast cancer effectively.
出处
《中国介入影像与治疗学》
CSCD
北大核心
2016年第1期52-55,共4页
Chinese Journal of Interventional Imaging and Therapy
关键词
乳腺肿瘤
新辅助化疗
磁共振成像
Argus软件
Breast neoplasms
Neoadjuvant chemotherapy
Magnetic resonance imaging
Argus software
作者简介
尹媛媛（1986-），女，山东潍坊人，硕士，医师。研究方向：磁共振影像诊断。E-mail：1986．yyy@163．com
[通信作者]王宏，中国人民武装警察部队总医院磁共振科，100039。E-mail：wanghongmri@sina．com
