摘要
【目的】观察羟考酮注射液对门诊行无痛纤维结肠镜检查患者的镇痛效果及不良反应。【方法】选择行无痛纤维结肠镜检查的患者120例，随机分为羟考酮组（O组）和芬太尼组（F组）。两组分别以羟考酮联合丙泊酚和芬太尼联合丙泊酚实施静脉全身麻醉，比较两组患者麻醉诱导前（T0）、检查开始前（T1）、检查开始时（T2）、结肠镜过肝曲时（T3）、结肠镜退出时（T4）、患者清醒时（T5）五个时间点的平均动脉压（MAP）、心率（HR）、动脉血氧饱和度（SpO2）、呼吸频率（RR）；记录检查持续时间、清醒时间、离院时间；丙泊酚总量及两组患者苏醒过程中恶心呕吐、头晕、肠绞痛等不良反应的发生率。【结果】所有患者均能顺利完成肠镜检查。T1、T2时间点F组HR、SpO2、RR明显低于O组（P〈0．05），两组患者检查时间、清醒时间、离院时间和丙泊酚总量差异均无统计学意义。O组术后肠绞痛发生的几率明显少于F组（P〈0．05）。【结论】丙泊酚复合羟考酮或芬太尼应用于无痛肠镜检查均安全有效，但羟考酮对于肠绞痛的镇痛效果更好，对于呼吸、循环系统影响更小，更适用于门诊纤维结肠镜检查术的麻醉。
[Objective]To observe the effect of oxycodone injection on the analgesic effect and adverse reaction of outpatients underwent painless fibreeolonoscopy.[Methods]The 120 cases of painless colonoscopy were randomly divided into oxycodone group （Group O） and fentanyl group （Group F）. The two groups were treated by intravenous anesthesia with oxycodone combined with propofol and fentanyl combined with propofol respectively. Elements like Pre-induction of anesthesia （To）, pre- start to check （T1）, at the beginning of check （T2）, through the hepatic flexure （T3）, colonoscopy quit（T4 ）, recovery time（T5 ）, five- time- points mean arterial pressure （MAP）, heart rate （HR）, arterial oxygen saturation （SpO2）, respiratory rate （RR） ; the incidence of nausea and vomiting, dizziness, colic and other adverse reactions in the two groups of patients were compared with, and the duration of waking time and the time away from hospital were recorded and checked; The total amount of propofol and the incidence of adverse reactions such as nausea, vomiting, dizziness and colic in the two groups were detected.[Resuits]All patients were successfully completed colonoscopy. AT time points of T1 and T2 , HR, SpO2 and RR in the Group F was significantly lower than those in the Group O （ P 〈0.05）. There was no significant difference between the two groups in the examination time, waking time, the time away from the hospital and the total amount of propofol. The probability of postoperative angina occurred in the Group O was obviously less than that of the Group F （ P 〈0.05）.[Conclusion]Propofol combined with oxycodone or with fentanyl for painless fibrecolonoseopy are safe and effective, but oxycodone is better with curing intestinal angina and has smaller effect on respiratory, circulatory system , which is more suitable for anesthesia in fibrecolonoscopy.
出处
《医学临床研究》
CAS
2015年第12期2296-2298,共3页
Journal of Clinical Research
作者简介
通讯作者，E—mail：huanghs2233@163．com
