摘要
目的探讨联合使用血清鳞状上皮细胞癌抗原（SCC-Ag）和宫颈液基薄层抗原检测（TCT）筛查宫颈癌的效果。方法选取笔者医院2012年9月～2014年8月1150例非妊娠期女性健康体检者,行TCT检查,并使用ELISA试剂盒检测所有患者血清中SCC-Ag值进行对比。结果TCT结果显示632例存在异常,518例正常。病理检查181例出现异常,其中97例CIN＋原位癌,76例鳞癌,8例腺癌。SCC-Ag在宫颈鳞状细胞癌组中最高,均明显高于另外3组,组间比较差异有统计学意义（P=0.000）。SCC-Ag诊断鳞癌的特异性和敏感度均高于TCT,两者联合使用后敏感度与特异性均有所升高,其中敏感度升高明显。TCT诊断CIN＋原位癌的敏感度与特异性明显高于SCC-Ag,但两者联合使用后敏感度有所增加,但特异性有所下降。结论虽然SCC-Ag对于宫颈癌诊断后病情监测与随访方面具有价值,但对筛查价值不大。SCC-Ag联合TCT有助于提高宫颈鳞癌早期诊断的敏感度,但对CIN＋原位癌的筛查价值较低。
Objective To investigate the value of serum squamous cell carcinoma antigen （SCC-Ag） combined liquid-based thinPrep cytology test （TCT） in screening cervical cancer. Methods Totally 1150 cases healthy women in our hospital from 2012 to 2014 were used TCT checks and used an ELISA kit to detect serum SCC-Ag values for all patients. Results The results of TCT were showed that 632 cases of abnormal, 518 cases of normal. 181 cases of abnormal pathology：97 cases of CIN ＋ carcinoma in situ, 76 cases of squamous cell carcinoma, 8 cases of adenocarcinoma. SCC-Ag was highest in cervical squamous cell carcinoma than the other three groups, the differences were significantly in the groups （P=0.000）. The specificity and sensitivity of SCC-Ag in diagnosis of squamous cell carcinoma were higher than TCT. Sensitivity and specificity were elevated in conjunction with the latter two, while the sensitivity was increased significantly. The sensitivity and specificity of TCT in diagnosis of CIN ＋ in situ were significantly higher than SCC-Ag. when combined use of both, the sensitivity was increased, specificity was decreased. Conclusion Although the SCC-Ag has the value of the condition monitoring and follow-up aspects of post-cancer diagnosis, but has the little value of screening. SCC-Ag joint TCT help improve the early diagnosis of cervical squamous cell sensitivity, but screening for CIN ＋ carcinoma in situ is lower.
出处
《医学研究杂志》
2015年第12期154-156,共3页
Journal of Medical Research
关键词
宫颈癌
鳞状上皮细胞癌抗原
人乳头瘤病毒
宫颈液基薄层细胞检测
Cervical cancer
Squamous cell carcinoma antigen
Human papilloma virus
Liquid- based cervical cytology test
