摘要
目的:分析噻托溴铵辅助治疗支气管扩张合并肺部感染的临床疗效。方法:将2017年1～12月我院治疗的108例支气管扩张合并肺部感染患者作为研究对象,应用随机数表法分为两组,各54例。对照组接受抗感染、吸氧、气道灌洗等常规对症治疗,观察组加用噻托溴铵治疗。观察两组临床疗效、不良反应及治疗前后肺功能指标、6min步行距离(6MWT)等。结果:与对照组总有效率74.07%相比,观察组总有效率90.74%相对较高,差异有统计学意义(P<0.05);治疗前两组1s用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1占预计值百分比(FEV1%)、6MWT对比,差异无统计学意义(P>0.05);治疗后与对照组FEV1(2.16±0.43)L、FVC(2.79±0.58)L、FEV1%(66.84±11.42)%、6MWT (302.96±40.15)m相比,观察组FEV1(2.79±0.62)L、FVC (3.61±0.74)L、FEV1%(78.92±13.56)%、6MWT(352.01±45.86)m相对较高,差异有统计学意义(P<0.05);两组不良反应发生率7.41%、5.56%相比,差异无统计学意义(P>0.05)。结论:噻托溴铵辅助治疗支气管扩张合并肺部感染安全性较高且疗效确切,利于增强肺功能,提升运动耐力。
Objective:To analyze the clinical efficacy of tiotropium bromide in treatment of bronchiectasis combined with pulmonary infection.Methods:108 patients with bronchiectasis combined with pulmonary infection treated in the hospital from January to December2017 were selected,and they were divided into two groups by random number table,with 54 cases in each group.Control group was given routine treatment with anti-infection,oxygen uptake and tracheal lavage,while observation group was treated with tiotropium bromide.The clinical efficacy,adverse reactions,indexes of pulmonary function,6-minute walking test(6 MWT)in two groups were observed.Results:The total effective rate of observation group(90.74%)was higher than control group(74.07%)(P<0.05);Before treatment,there was no statistical difference in the forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1%,6 MWT between the two groups(P>0.05);After treatment,the FEV1,FVC,FEV1%,6 MWT in observation group[(2.79±0.62)L,(3.61±0.74)L,(78.92±13.56)%,(352.01±45.86)m]were higher than control group[(2.16±0.43)L,(2.79±0.58)L,(66.84±11.42)%,(302.96±40.15)m](P<0.05);There was no statistical statistical difference in the incidence of adverse reactions between the two groups(7.41%VS 5.56%)(P>0.05).Conclusion:Tiotropium bromide in treatment of bronchiectasis combined with pulmonary infection is safe and effective,it can enhance pulmonary function and increase exercise tolerance.
作者
孟庆丽
Meng Qingli(Pharmacy of runan county Traditional Chinese Medicine Hospital in Zhumadian City,Henan Province,463300)
出处
《北方药学》
2019年第4期12-13,共2页
Journal of North Pharmacy
关键词
支气管扩张
肺部感染
噻托溴铵
临床疗效
肺功能
Bronchiectasis
Pulmonary infection
Tiotropium bromide
Clinical efficacy
Pulmonary function
