摘要
目的改进尼莫地平的合成工艺。方法以间硝基苯甲醛,3-氨基巴豆酸异丙酯和乙酰乙酸甲氧乙酯为原料,经闭环反应制备尼莫地平。结果通过新合成方法,减少了合成步骤,总收率为72.1%。结论本工艺操作简便,成本较低,适于工业化生产。
Objective To improve the synthesis process of nimodipine. Methods Nimodipine was prepared from 3-nitrobenzaldehyde, isopropyl 3-aminocrotonate and 2-methoxyethyl acetoacetate after ring-closing reaction. Results By the new method, the synthetic steps are reduced, and the total yield of nimodipine reached 72.1%. Conclusion A simple, easily controlled and cost saving process for the synthesis ofnimodipine is attainable.
出处
《食品与药品》
CAS
2015年第6期411-413,共3页
Food and Drug
作者简介
李帅（1982-），男，山东淄博人，工程师，研究方向为药物合成E-mail：86585378@qq．com
