摘要
目的探讨阿奇霉素辅助治疗小儿支气管哮喘疗效及对患者炎性因子水平的影响。方法选取内蒙古自治区人民医院和内蒙古自治区妇幼保健院收治的112例符合纳入标准的小儿支气管哮喘患者,分为对照组(56例)和观察组(56例)。常规治疗的基础上对照组给予孟鲁司特治疗,观察组在对照组的基础上给予阿奇霉素辅助治疗。观察比较两组患者临床疗效、症状、体征消失时间、肺功能改善情况、炎性因子水平及不良反应发生情况。结果观察组治疗总有效率为96.4%,明显高于对照组的85.7%,差异有统计学意义(P<0.05)。与对照组相比,观察组治疗后咳嗽、气促、哮鸣音等症状体征消失时间显著缩短,肺功能指标第1秒最大呼气量(FEV1)、FEV1/用力肺活量、最大呼气峰流速显著升高,炎性因子白细胞介素-2(IL-2)、IL-6水平显著下降,而IL-10水平显著升高,差异均有统计学意义(P<0.05)。治疗过程中未出现严重不良反应,观察组不良反应发生率为16.1%,与对照组的5.4%比较差异无统计学意义(P>0.05)。结论阿奇霉素辅助治疗小儿支气管哮喘疗效可靠,能够显著提高临床疗效,缩短临床症状和体征消失时间,改善肺功能,并能明显减轻机体炎性反应,且不良反应轻微,值得临床进一步研究。
Objective To investigate the clinical effect of azithromycin adjuvant therapy in children with bronchial asthma and its effects on the levels of inflammatory factors.Methods 112 cases of children with bronchial asthma meeting the inclusion criteria were selected from People′s Hospital of Inner Mongolia Autonomous Region and Maternal and Child Health Hospital of Inner Mongolia Autonomous Region,and divided into control group（n=56）and observation group（n=56）.Besides conventional treatments,control group was treated by montelukast,while observation group was treated by montelukast and azithromycin adjuvant therapy.The curative efficacy,disappearance times of clinic symptoms and physical signs,improvement of pulmonary function,levels of inflammatory factors and adverse reactions in two groups were observed and compared.Results Observation group had a total therapeutic efficiency ratio of 96.4%,which was higher than that of control group（85.7%）,with statistical difference（P〈0.05）.After the treatment,disappearance times of cough,shortness of breath and wheezing rale in observation group were statistically shorter,and pulmonary indices of FEV1,FEV1/FVC,PEF were statistically higher,respectively comparing with control group.As to the inflammatory factors,in comparison with control group,the levels of IL-2and IL-6were statistically lower,and the level of IL-10 was statistically higher in observation group（P〈0.05）.During the treatment,there was no severe case of adverse reaction.And the incidences of adverse reactions in observation group was 16.1%,which was similar with that of control group（5.4%）,and there was no significant difference（P〉0.05）.Conclusion Azithromycin adjuvant therapy is effective for children with bronchial asthma.And it can significantly increase curative efficacy,shorten disappearance time of clinic symptoms and physical signs,improve pulmonary function,and alleviate inflammatory reaction with minor adverse reactions.
出处
《检验医学与临床》
CAS
2015年第24期3663-3665,共3页
Laboratory Medicine and Clinic
关键词
阿奇霉素
小儿支气管哮喘
肺功能
炎性因子
azithromycin
bronchial asthma in children
pulmonary function
inflammatory factors
作者简介
孟晓波，女．硕士，主治医师，主要从事儿科疾病疗丽的研究。
通讯作者，Email：ztmngxm7335@sohu．com.
