摘要
锌指核酸酶(Zinc finger nucleases,ZFN)、转录激活子样效应因子核酸酶(Transcription activator-like effector nucleases,TALEN)和成簇规律间隔短回文重复序列(Clustered regularly interspaced short palindromic repeats,CRISPR)/Cas9核酸酶是三个主要的基因组定向编辑技术。它们在基因功能研究、物种改造和疾病预防与基因治疗等各个领域都有重大科学研究及应用价值。每个技术背后都有过和有着激烈的知识产权归属之争。本文归纳总结这三大基因组定向编辑技术的知识产权,以期为研发具有自主知识产权的基因组编辑工具提供一些借鉴,也为现阶段高校创新创业教育提供启示。
Zinc finger nuclease, transcription activator-like effector nuclease, and clustered regularly interspaced short palindromic repeats/Cas9 nuclease are important targeted genome editing technologies. They have great significance in scientific research and applications on aspects of functional genomics research, species improvement, dis-ease prevention and gene therapy. There are past or ongoing disputes over ownership of the intellectual property behind every technology. In this review, we summarize the patents on these three targeted genome editing technologies in order to provide some reference for developing genome editing technologies with self-owned intellectual property rights and some implications for current innovation and entrepreneurship education in universities.
出处
《遗传》
CAS
CSCD
北大核心
2015年第12期1258-1262,共5页
Hereditas（Beijing)
基金
重庆市教委研究生教改项目“全球视野高层次人才培养的区域性跨院校支撑平台”(编号:YJG123104)
重庆市教委研究生优质课程《高级微生物学》
西南大学本科生教改项目(编号:2013JY201)
教育部新世纪优秀人才资助计划(编号:NCET-11-0703)
国家自然科学基金(编号:81371851,81071316,81271882,81301394)
中央高校基本科研业务费(编号:XDJK2011D006,XDJK2012D011,XDJK2012D007,XDJK2013D003,XDJK2014D040)资助
作者简介
樊祥宇，博士，讲师。研究方向：噬菌体功能基因组学。E—mail：fxysnd@126．com
通讯作者：谢建平，博士，研究员。研究方向：人类重要致病菌的致病耐药机理和新干预措施研发。Tel：86—23—68367108；E—mail：georgex@swu．edu．cn
