摘要
Thermosensitive drug delivery systems （DDSs） face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near- infrared （NIR） photothermal Cu175S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine （DOX） loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions （pH = 7.4, 37 ~C） for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous long- term NIR irradiation. Based on the stable and high photothermal efficiency （55.8%）, pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstratin~ remote and noninvasive control.
Thermosensitive 药交货系统(DDS ) 面对主要挑战，例如遥远、可重复的控制在 vivo 温度，尽管这些能增加药的治疗学的功效。处理这个问题，我们涂在红外线附近(NIR ) photothermal Cu <sub>1.75</sub > 有 pH/thermos-sensitive 聚合物由的 S nanocrystals 在 situ 聚合。装载内容的 doxorubicine (纪录影片) 直到 40 wt.% ，与纪录影片在正常生理的条件下面正在被漏的不到 8.2 wt.%(pH = 7.4， 37 吗？
