Srx与E-cadherin在宫颈鳞癌组织中的表达及临床意义被引量：7

The expression and clinical significance of Srx and E-cadherin in cervical squamous cell carcinoma tissue

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摘要目的探讨硫氧还原蛋白(Sulfiredoxin,Srx)与上皮细胞黏附分子E-钙黏蛋白(E-cadherin)在宫颈鳞癌组织中的表达及临床意义。方法采用免疫组织化学SABC法检测30例正常宫颈上皮组织(NC)、20例重度子宫颈上皮内瘤变(HSIL)及104例宫颈鳞状细胞癌(CSCC)组织中Srx和E-cadherin蛋白的表达情况,分析两者与宫颈鳞癌临床病理特征的关系及两者表达的相关性。结果 Srx在宫颈鳞癌组织中呈现高表达,而E-cadherin在鳞癌组织中表达明显降低,2蛋白阳性表达率在3组中比较差异具有统计学意义(P<0.05),且Srx与E-cadherin蛋白表达呈负相关。宫颈鳞癌组织中Srx的表达与淋巴结转移、肿瘤浸润深度及有无脉管浸润有关(P<0.05),而与患者年龄、临床分期、肿瘤大小及癌组织分化程度无关(P>0.05)。E-cadherin的阳性表达率与肿瘤大小、组织分化程度及淋巴结转移关系密切(P<0.05)。结论宫颈鳞癌组织中Srx的高表达与恶性临床病理特征密切相关,并与Ecadherin蛋白表达呈负相关,提示Srx可能通过调控EMT促进宫颈鳞癌进展。 This study designed to investigate the expression and clinical significance of Sulfiredoxin（Srx） and E-cadherin in cervical squamous cell carcinoma tissues. Immunohistochemical SABC method was used to detect the expression levels of Srx and E-cadherin in specimens from 30 cases from normal cervical squamous cell epithelium（NC）, 20 cases of high-grade squamous intraepithelial lesions（HSIL） and 104 cases of cervical squamous cell carcinoma（CSCC）. The correlation between Srx expression and E-cadherin expression and the correlation between the two proteins and clinicopathological characteristics of cervical squamous cell carcinoma were analyzed. Data showed that the expression of Srx was up regulated but E-cadherin was obviously decreased in CSCC tissues; the differences of the positive expression rate of Srx and E-cadherin in three groups were statistically significant（P〈0.05）; Srx and E-cadherin expression were negatively correlated in CSCC tissues. Srx was signifiantly correlated with cervical squamous cell carcinoma of lymph node metastasis, cancer invasion depth and haemal tube infiltration（P〈0.05）, but Srx expression did not correlate with age, clinical stage（FIGO）, volume of primarily tumor and degree of differentiation（P〈0.05）. E-cadherin was closely correlated with cervical squamous cell carcinoma of primarily tumor volume, differentiation degree and lymph node metastasis（P〈0.05）. In conclusion, the overexpression of Srx in cervical squamous cell carcinoma is correlated with malignant clinicopathological characteristics, and negatively correlated with E-cadherin expression, which indicates that Srx may promote the development of cervical squamous cell carcinoma by regulating EMT.

作者陈小燕刘琴兰康云王珊王辉

机构地区重庆医科大学附属第一医院妇产科

出处《免疫学杂志》 CAS CSCD 北大核心 2015年第12期1067-1071,共5页 Immunological Journal

关键词硫氧还原蛋白 E-钙黏蛋白宫颈鳞癌免疫组组化学 Sulfiredoxin E-cadherin Cervical squamous cell carcinoma Immunohistochemistry

分类号 R737.33 [医药卫生—肿瘤]

作者简介通信作者：王辉．E—mail：15310918845@163．com

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