摘要
目的探讨丹参酮ⅡA磺酸钠联合依那普利对慢性肺源性心脏病急性加重期患者血液流变学和心肺功能的影响。方法将2012年10月至2014年4月我院收治的慢性肺心病急性加重患者92例分为治疗组和对照组各46例,两组均在常规治疗的基础上应用依那普利治疗,治疗组加用丹参酮ⅡA磺酸钠注射液治疗。结果治疗后,治疗组总有效率为91.3%,明显优于对照组76.1%的总有效率;两组患者的血气分析指标、血流动力学指标及肺动脉收缩压等均较治疗前有明显改善,而且治疗组较对照组改善更为显著,差异有统计学意义(P<0.05);两组不良反应轻微。结论慢性肺心病急性加重期患者应用丹参酮ⅡA磺酸钠与依那普利联合治疗,临床效果显著,安全可靠。
Objective To observe the effect of tanshinone Ⅱ A sulfonate plus enalapril on blood rheology, heart and lung function in patients of chronic cor pulmonale exacerbation. Methods 92 patients with chronic cor pulmonale exacerbation in our hospital from October 2012 to April 2014 were randomly divided into experimental group and control group. The conventional treatment additionally enalaprii was given in the two groups; while in experimental group tanshinone n A sulfonate injection was added. Results The effective rate in experimental group was 91.3%, significantly higher than that in the control group which was 76.1 % （ P〈 0.05）. The index of blood gas analysis, hemodynamie parameters and pulmonary arterial pressure in the two groups were significantly improved, especially in the treatment group, the difference was statistically significant（P〈0.05）. The adverse reactions in the two groups were mild. Conclusion The combined treatment of tanshinone Ⅱ A sulfonate and Enalapril on patients of chronic cor pulmonale exacerbation has remarkable clinical effect, safe and reliable.
出处
《中国冶金工业医学杂志》
2015年第6期633-634,共2页
Chinese Medical Journal of Metallurgical industry
