摘要
【目的】观察慢性肾脏病（CKD）患者头发氨基酸含量的变化及护肾Ⅱ号方对其干预的影响,为＂肾其华在发＂理论提供物质基础。【方法】100例慢性肾脏病1~4期患者按随机数字表法分为对照组和治疗组,各50例。20例健康志愿者纳入正常组。对照组给予西医常规治疗,治疗组在对照组治疗的基础上口服护肾Ⅱ号,2组疗程均为12个月。采用高效液相色谱分析法,检测其头发氨基酸含量的变化。【结果】治疗前,对照组、治疗组14种氨基酸含量均显著下降,与健康组比较,差异有统计学意义（P〈0.05）;治疗后,对照组和治疗组14种氨基酸含量均较治疗前显著升高,差异有统计学意义（P〈0.05）,且治疗组作用优于对照组,差异有统计学意义（P〈0.05）。【结论】肾功能异常时头发氨基酸含量发生变化可能是＂肾其华在发＂理论的物质基础之一。
Objective To investigate the changes of hair amino acids contents in patients with chronic kidney disease at stage 1-4（CKD 1-4） and the intervention effect of Hushen No.Ⅱ, thus to provide modern medical evidences for the theory of kidney having its manifestations in hair. Methods One hundred cases of patients suffering from CKD 1-4 were recruited and were randomly divided into control group and treatment group, 50 cases in each group. And twenty healthy volunteers were included in normal group. The treatment group and control group received conventional treatment, and the treatment group were additionally treated with Hushen No. Ⅱ orally, the treatment lasting 12 months. And then high performance liquid chromatography was used to test the changes of hair amino acids of the three groups before and after treatment. Results Compared with the normal group, 14 kinds of amino acids in the hair of the control group and the treatment group were significantly low（P〈0.05） before treatment. After treatment, 14 kinds of amino acids in the hair of the control group and the treatment group were significantly increased（ P〈0.05） as compared with those before treatment, the increase of the treatment group being superior to the control group（P〈0.05）. Conclusion The abnormal change of 14 kinds of amino acids in the hair of patients with abnormal renal function may contribute to the modern medical material basis of the theory of kidney having its manifestations in hair.
出处
《广州中医药大学学报》
CAS
2015年第6期988-992,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家临床重点专科建设项目(编号:FW20113289)
湖北省自然科学基金重点项目(编号:2014CFA085)
湖北省医学领军人才培养工程专项经费资助项目(编号:鄂卫生计生发[2013]4号)
关键词
慢性肾脏病/中药疗法
护肾Ⅱ号/治疗应用
肾其华在发
氨基酸
色谱法
高压液相
Chronic kidney disease / TCD therapy
Hushen No.Ⅱ / therapeutic use
Theory of kidney having its manifestations in hair
Amino acids
Chromatography
high performance liquid
作者简介
巴元明（1961-），男，教授，博士研究生导师；E-mail：1723426138@qq．com
通讯作者：王林群，男，博士研究生；E-mail：wanglinqun-004@163．com
