摘要
目的评价加减薯蓣丸联合西药及分散内观认知疗法（DNCT）对偏执型精神分裂症患者康复效果的影响,探讨优化的治疗方案。方法将120例偏执型精神分裂症康复期女性患者随机分为研究组和对照组各60例。对照组在原有西药治疗的基础上给予分散内观认知疗法,研究组在对照组的基础上给予加减薯蓣丸。治疗16周后评价治疗前后2组患者的治疗效果、认知功能及生活质量改善情况。结果与治疗前比较,①2组患者的阳性症状量表评分、阴性症状量表评分、一般精神病理量表评分及PANSS量表总分均有所下降,差异均具有统计学意义（P〈0.05-0.01）;研究组优于对照组（P〈0.05-0.01）。②2组患者的认知功能各维度评分均得到改善（P〈0.05-0.01）,其中研究组患者的语言流畅性、数字序列、代币运动评分高于对照组（P〈0.05）。③2组患者SQLS量表总分及各维度评分均有所改善（P〈0.05-0.01）,其中研究组患者SQLS量表总分显著低于对照组患者（P〈0.05）。结论加减薯蓣丸治疗可以提高偏执型精神分裂症患者的治疗效果,更好的改善患者的认知功能和生活质量。
OBJECTIVE To evaluate the effect of dioscorea modified pill combined with western medicine and discontiguous naikan cognitive therapy on female patients with paranoid schizophrenia and to investigate optimal therapy for treatment.METHODS 120 female patients with paranoid schizophrenia in the recovery status were randomly divided into the study group and the control group with 60 cases in each group.Patients in the control group received the Western medicine therapy and discontiguous naikan cognitive therapy.Patients in the study group were additionally given dioscorea modified pill compared with the control group.The therapeutic effect,cognitive function and quality of life in two groups were evaluated after 16-week treatment.RESULTS ①After treatment,positive symptoms scale score,negative symptoms scale score,general psychopathology scale score and the PANSS total score of both the groups were declined,and the differences were statistically significant（P〈0.05-0.01）;the decline in the study group was more obvious than that of the control group（P〈0.05-0.01）.② After treatment,the scores of every dimensions in BACS were improved in patients of both the groups（P〈0.05-0.01）.The language fluency score,score of symbol coding sequence of numbers,tokens and sports in the study group were higher than those of the control group（P〈0.05）.③After treatment,SQLS,Scale total score and each factor score in SQLS Scale in the two groups were improved（P〈0.05-0.01）;and the total score of SQLS in the study group was lower than the control group（P〈0.05）.CONCLUSION Dioscorea modified pill therapy may enhance the effect for the treatment and improve cognitive function and quality of life of patients with paranoid schizophrenia.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2015年第6期589-592,共4页
Journal of Nanjing University of Traditional Chinese Medicine
关键词
加减薯蓣丸
分散内观认知治疗
精神分裂症
认知功能
dioscorea modified pills
discontiguous NaiKan cognitive therapy
schizophrenia
cognitive function
作者简介
刘旭恩（1981-），男，河南新乡人．新乡医学院第二附属医院住院医师。
