摘要
目的研究孤独症儿童血浆多不饱和脂肪酸及血清肉毒碱水平变化,并探讨其是否与胃肠道反应存在相关性。方法选取2012年3月—2015年5月间于张家口市妇幼保健院进行诊治的37例孤独症儿童作为研究对象,并于同时间段内选取与其相匹配的院内体检健康儿童40例作为健康对照组,应用气相色谱法检测所有研究对象血浆中多不饱和脂肪酸水平,应用液相色谱质谱联用法检测血清中肉毒碱水平,比较所得数据并进行统计分析。结果孤独症儿童多不饱和脂肪酸和肉毒碱水平较健康对照组显著降低,ω-6/ω-3比值则显著高于健康对照组。孤独症儿童肉毒碱降低和ω-6/ω-3比值升高呈显著正相关(r=0.61,P<0.05);儿童孤独症等级评定表评测结果显示16例儿童属轻-中度孤独症,21例属重度孤独症。重度孤独症儿童多不饱和脂肪酸和肉毒碱水平低于轻-中度孤独症儿童,差异具有统计学意义;20例(54.1%)孤独症儿童出现胃肠道反应,表现包含周期性难以解释的上腹部疼痛、慢性便秘、腹胀及反复发作的腹泻等。与无胃肠道反应的患儿相比,有胃肠道反应的孤独症患儿肉毒碱和多不饱和脂肪酸明显降低,同时ω-6/ω-3比值明显升高。结论血浆中多不饱和脂肪酸和血清中肉毒碱水平下降可能与孤独症儿童病程进展有关,同时与胃肠道反应的发生和发展有关。
Objective To investigate the relationship between the levels of plasma polyunsaturated fatty acids（PUFA）and serum carnitine and gastrointestinal reaction in autistic children. Methods From March 2012 to May 2015,37 cases ofautistic children in maternal and children health hospital of Zhangjiakou were chosen as treated group,and at the same time,40 cases of medical healthy children as healthy control group. Plasma levels of PUFA were measured by gas chromatographicmethod. Serum carnitine were measured by liquid chromatographic mass spectrometry,and the data between two groups wereanalyzed. Results The levels of PUFA and carnitine in autistic children were significantly lower than that in the healthycontrols,but ω-6/ω-3 ratio was significantly higher than that of healthy controls. The reduction of carnitine in autistic childrenwas positive in correlation with the increase of ω-6/ω-3 ratio,significantly（r =0.61,P〈0.05）; The Childhood Autism RatingScale results showed that 16 cases were mild to moderate autism and 21 cases were severe autism. The levels of PUFA andcarnitine in severe autistic children were lower than mild to moderate autistic children. The differences were statisticallysignificant（P〈0.05）. About 20 cases（54.1%） of autistic children had gastrointestinal reaction,including recurrentunexplained attacks of epigastric pain,chromic constipation,bloating and recurrent attacks of diarrhea. The levels of carnitineand PUFA in autistic children with gastrointestinal reaction were significantly lower than patients without such reaction,whilethe ω-6/ω-3 ratio were higher significantly. Conclusion Reduction of plasma PUFA and serum carnitine may be associatedwith the progression of disease and gastrointestinal reaction in autistic children.
出处
《中国热带医学》
CAS
2015年第10期1224-1227,共4页
China Tropical Medicine
关键词
孤独症儿童
胃肠道反应
肉毒碱
多不饱和脂肪酸
Autism children
Gastrointestinal reaction
Carnitine
Polyunsaturated fatty acids
作者简介
张晓俞（1983-），女，本科，主治医师，研究方向：儿童胃肠道反应发病机制。
