摘要
目的对比观察地特胰岛素联合门冬胰岛素和甘精胰岛素联合门冬胰岛素治疗2型糖尿病的临床疗效。方法选取口服降糖药物及饮食控制治疗无效或效果不佳的2型糖尿病患者134例,将其随机分为A组和B组各67例。A组患者采用地特胰岛素联合门冬胰岛素治疗,B组患者采用甘精胰岛素联合门冬胰岛素治疗,比较2组患者的临床疗效。结果治疗后2组空腹血糖(FPG)、餐后2h血糖(2h PG)、糖化血红蛋白(Hb A1c)水平均较治疗前降低,差异有统计学意义(P<0.05)。治疗后FPG、2h PG、Hb A1c水平均恢复到正常值范围或接近正常水平,组间差异无统计学意义(P>0.05)。2组患者的低血糖发生率分别为4.5%、6.0%,差异无统计学意义(P>0.05);但A组患者血糖达标时间短于B组,差异有统计学意义(P<0.05)。结论地特胰岛素和甘精胰岛素分别联合门冬胰岛素治疗2型糖尿病的临床效果均较佳,不良反应发生率低;但地特胰岛素联合门冬胰岛素治疗2型糖尿病的血糖达标时间短,具有更高的临床推广价值。
Objective To observe and compare the curative effect of insulin detemir combined with insulin aspart and insulin glargine combined with insulin aspart on treating type 2 diabetes. Methods 134 type 2 diabetes patients who were treated with oral hypoglycemic drugs and diet control and with non effect were randomly divided into group A and group B,each group with 67 cases. Group A was treated with insulin detemir combined with Insulin aspart,and group B was treated with insulin glargine combined with Insulin aspart. The clinical effect of two groups were compared. Results After treatment,fasting blood glucose（ FPG）,postprandial 2h blood glucose（ 2h PG）,glycosylated hemoglobin（ Hb A1c） levels were significantly lower than before,the difference were statistically significant（ P〈0. 05）. The levels of FPG,2h PG and Hb A1 c were returned to normal level or near normal level,and there was no significant difference between the groups（ P〉0. 05）. The incidence of hypoglycemia of the two groups were 4. 5% and 6. 0%,the difference was not statistically significant（ P〉0. 05）; but blood glucose standard time of group A was shorter than that of group B,the difference was statistically significant（ P〈0. 05）. Conclusion Both insulin detemir combined with insulin aspart and insulin glargine combined with insulin aspart have good effect on treating type 2 diabetes and have low complication rate,but the blood glucose standard time of detemir insulin combined with glarine insulin is shorter,so it has higher promotion and use value in clinical.
出处
《临床合理用药杂志》
2015年第31期1-2,共2页
Chinese Journal of Clinical Rational Drug Use
