摘要
目的 探讨苦参素注射液对治疗慢性乙型肝炎患者的临床疗效.方法 慢性乙型肝炎患者64例,随机分为观察组和对照组,各32例.对照组患者给予抗病毒、保肝及控制转氨酶水平等常规治疗措施,观察组患者在常规治疗基础上给予苦参素注射液治疗.结果 观察组患者总有效率为93.75％,对照组患者总有效率为65.62％,其差异具有统计学意义（P＜0.05）.观察组患者血清IFN-γ、IL-10及DNA水平下降幅度高于对照组患者血清IFN-γ、IL-10及DNA水平下降幅度,差异具有统计学意义（P＜0.05）.观察组患者谷丙转氨酶（ALT）、谷草转氨酶（AST）及总胆红素（TbiL）水平下降幅度高于对照组患者ALT、AST及TbiL水平下降幅度,其差异具有统计学意义（P＜0.05）.观察组患者DNA及HbeAg阳性率低于对照组患者DNA及HbeAg阳性率,差异具有统计学意义（P＜0.05）.结论 苦参素注射液治疗慢性乙型肝炎能够降低血清IFN-γ、IL-10及乙型肝炎病毒DNA水平,减轻炎症反应,调节机体免疫应答,抑制乙型肝炎病毒DNA体内复制作用,促进肝功能不断好转,提高慢性乙型肝炎患者治疗效果.
Objective To investigate the clinical effect of Marine Injection on treatment of patients with chronic hepatitis B.Methods 64 patients with chronic hepatitis B were randomly divided into the observation group and the control group, 32 cases in each.For the control group, patients were treated with anti-viral, liver care and aminopherase levels controling and other conventional treatment measures.For the observation group, patients were treated with Marine Injection on the basis of conventional therapy.Results The total efficiency rate of the observation group was 93.75% and 65.62% in the control group.The difference was statistically significant （P 〈 0.05） between two groups.Serum IFN-γ, IL-10 and DNA levels of the observation group declined higher than that of the control group.The difference was statistically significant （P 〈 0.05）.ALT, AST and TbiL levels of the observation group declined higher than that of the control group.The difference was statistically significant （P 〈 0.05）.The positive rate of DNA and HbeAg in the observation group patients were lower than that of the control group patients, the difference was statistically significant （P 〈 0.05）.Conclusions Marine Injection has good clinical effect to treat patients with chronic hepatitis B for reducing serum IFN-γ, IL-10 and HBV DNA levels, alleviating inflammation, regulating the immune response, inhibiting replication of hepatitis B virus DNA in vivo, improving liver function.
出处
《国际病毒学杂志》
2015年第5期319-322,共4页
International Journal of Virology
