摘要
目的:探讨四君子汤合黄芪辅助饮食运动疗法治疗妊娠糖尿病气阴两虚证临床效果。方法:研究对象选取本院近年来收治妊娠糖尿病气阴两虚证患者240例,采用随机数字表法分为对照组和中医组,每组各120例;其中对照组患者采用常规饮食运动疗法治疗,中医组患者则在此基础上加用四君子汤合黄芪辅助治疗;比较两组患者临床疗效、治疗前后血糖、血脂及肾脏功能指标水平,妊娠结局等。结果:对照组和中医组患者治疗总有效率分别为78.33%,91.67%;中医组患者临床疗效显著优于对照组,差异有统计学意义(P<0.05);对照组患者治疗后空腹血糖(FPG),餐后2 h血糖(2 h PG)及糖化血红蛋白(Hb A1c)指标分别为(9.77±1.03)mmol·L-1,(11.30±1.64)mmol·L-1,(9.84±1.10)%;中医组患者治疗后FPG,2 h PG及Hb A1c指标分别为(5.48±0.62)mmol·L-1,(8.62±1.27)mmol·L-1,(7.03±0.64)%;中医组患者治疗后血糖、血脂及肾脏功能指标水平均显著优于对照组治疗后,差异有统计学意义(P<0.05);中医组患者早产、子痫前期、羊水过多、新生儿窘迫征及新生儿高胆红素血症发生率均显著低于对照组,差异有统计学意义(P<0.05);两组患者剖宫产和妊娠期高血压发生率比较差异无统计学意义。结论:四君子汤合黄芪辅助饮食运动疗法治疗妊娠糖尿病气阴两虚证可有效缓解糖尿病症状,控制血糖和血脂水平,改善肾脏功能,并对妊娠结局具有积极影响。
Objective： To investigate clinical effects of Sijunzi Tang,Astragalus Radix assisted with diet exercise therapy in treatment of gestational diabetes mellitus with deficiency of Qi and Yin type. Method： Two hundred and forty patients with gestational diabetes mellitus with deficiency of Qi and Yin type were chosen in recent years in our hospital and randomly divided into both group including control group（ 120 patients） with routine diet exercise therapy and traditional Chinese medicine（ TCM） group（ 120 patients） with Sijunzi Tang combined with astragalus on the basis of control group; and the clinical efficacy,levels of blood glucose,blood lipids and renal function index before and after treatment and pregnancy outcome of both groups were compared.Result： The clinical efficacy of control group and TCM group were separately 78. 33%,91. 67%; the clinical efficacy of TCM group was significantly better than control group（ P〈0. 05）. The value of fasting plasma glucose（ FPG）,2 h plasma glucose（ 2 h PG） and glycated hemoglobin A1c（ Hb A1c） of control group after treatment were separately（ 9. 77 ± 1. 03） mmol·L- 1,（ 11. 30 ± 1. 64） mmol·L- 1,（ 9. 84 ± 1. 10） %. The value of FPG,2h PG and Hb A1 c of TCM group after treatment were separately（ 5. 48 ± 0. 62） mmol·L- 1,（ 8. 62 ± 1. 27） mmol·L- 1,（ 7. 03 ± 0. 64） %; the levels of blood glucose,blood lipids and renal function index after treatment of TCM group was significantly better than control group and before treatment（ P〈0. 05）. The incidence of preterm birth,preeclampsia,polyhydramnios,neonatal respiratory distress syndrome and neonatal hyperbilirubinemia of TCM group was significantly lower than control group（ P〈0. 05）. There was no significant difference in incidence of cesarean section and pregnancy induced hypertension between 2 groups. Conclusion： Sijunzi Tang,astragalus assisted with diet exercise therapy in treatment of gestational diabetes mellitus with deficiency of Qi and Yin type can efficiently relieve the diabetes symptoms,control the levels of blood glucose and blood lipid,improve the renal function and have the positive effect on the pregnancy outcome.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第21期181-184,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
青海省科技厅应用基础研究计划项目(2015-ZJ-765)
关键词
四君子汤
妊娠糖尿病
气阴两虚
疗效
Sijunzi Tang
gestational diabetes mellitus
deficiency of Qi and Yin
clinical effect
作者简介
[第一作者]谢玲，副主任医师，从事危重产科相关方面的研究，Tel：18997285541，E-mail：enjkfgfd@163．com
