摘要
目的:应用透明质酸钠联合索利那新治疗膀胱肿瘤术后由灌注化疗药物引起的膀胱炎,观察其疗效。方法:44例膀胱癌术后因行化疗药物灌注引起化学性膀胱炎患者,按就诊顺序随机分为对照组和治疗组2组各22例,对照组单独给予琥珀酸索利那新治疗;治疗组给予透明质酸钠膀胱灌注联合服用琥珀酸索利那新治疗。治疗4周后,评价其疗效及安全性。结果:2组患者治疗后平均24 h内排尿次数、尿急次数、急迫性尿失禁次数、膀胱区疼痛次数均较治疗前有明显改善(P<0.01);其中治疗组在改善平均24 h内排尿次数和膀胱区疼痛次数方面均优于对照组(P<0.01),2组在改善平均24 h内尿急次数和急迫性尿失禁次数方面差异无统计学意义(P>0.05)。治疗组在治疗后24 h内平均每次排尿量方面较治疗前有明显改善(P<0.01),而对照组治疗前后差异无统计学意义(P>0.05)。结论:透明质酸钠联合索利那新治疗由膀胱灌注化疗药物引起的化学性膀胱炎,能明显减轻膀胱刺激症状,增加膀胱容量,减轻患者痛苦,其疗效优于单用索利那新。
Objective：To explore the effects of sodium hyaluronate combined with solifenacin on cystitis caused by chemical drugs. Methods：Forty-four patients with chemical cystitis caused by chemical drugs after operation of bladder cancer were divided into the control group and treatment group which were treated with solifenacin and sodium hyaluronate combined with solifenacin,respectively. The clinical efficacy and safety in all patients were evaluated in 4 weeks after treatment. Results：Compared with before treatment,the mean number of micturition,urgency episode,urge incontinence and vesical pain per day in two groups were significantly improved after treatment（P〈0. 01）,the improvement in the number of micturition and vesical pain of the treatment group were better than that of the control group（P 〈0. 01）,the differences of the number of urgency episode and urge incontinence between two groups were not statistically significant（P〉0. 05）. The mean urine output in treatment group improved significantly after treatment（P〈0. 01）,but it was not statistically significant in control group（P 〉 0. 05）. Conclusions：The treatment of sodium hyaluronate combined with solifenacin can obviously alleviate the bladder irritative symptom,increase bladder capacity,alleviate the suffering of the patients with chemical cystitis,the effect of which is better than that of solifenacin.
出处
《蚌埠医学院学报》
CAS
2015年第10期1349-1351,共3页
Journal of Bengbu Medical College
关键词
膀胱肿瘤
透明质酸钠
索利那新
化学性膀胱炎
膀胱灌注
bladder tumor
sodium hyaluronate
solifenacin
chemical cystitis
intravesical instillation
作者简介
曹勇（1981-），男，硕士，主治医师．
