摘要
目的 研究不同剂量戊酸雌二醇对宫腔镜术后宫腔粘连状况的影响。方法 选取2013年3月~2014年5月该院收治的宫腔镜手术患者70例,根据随机数字表法将患者分为A组和B组,每组35例。其中A组给予戊酸雌二醇3 mg/次,1次/d,B组给予戊酸雌二醇3 mg/次,3次/d,两组均用药3个月。治疗后行超声检测两组子宫内膜厚度,并比较两组患者临床疗效、宫腔粘连发生率、月经恢复率及不良反应发生率。结果 B组总有效率（97.1%）显著高于A组（68.6%）,两组比较差异有统计学意义（P〈0.05）;B组宫腔粘连发生率显著低于A组,月经恢复率显著高于A组,两组比较差异均有统计学意义（P〈0.05）;B组子宫内膜厚度显著大于A组,差异有统计学意义（P〈0.05）;两组不良反应发生率比较,差异无统计学意义（P〉0.05）。结论 每天应用9 mg戊酸雌二醇应用于宫腔镜术后具有较好的疗效,能有效促进患者月经恢复,促进子宫内膜增生,有效防止宫腔再粘连。
Objective To study the effects of different doses of estradiol valerate on intrauterine adhesion after hysteroscopic surgery. Methods Seventy patients receiving hysteroscopic surgery in the hospital from March 2013 to May 2014 were selected and divided into group A and group B according to random number table, 35 patients in each group. The patients in group A were treated by estradiol valer- ate, 3 mg per time, once a day ; the patients in group B were treated by estradiol valerate, 3 mg per time, three times a day, all the patients in the two groups were treated for three months. After treatment, ultrasonography was performed to measure endometrial thicknesses in the two groups; the clinical effects, the incidence rates of intrauterine adhesion, the recovery rates of menstruation, and the incidence rates of adverse reactions in the two groups were compared. Results The total effective rate in group B was 97. 1%, which was significantly higher than that in group A （68.6%） （P〈0.05） ; the incidence rate of intrauterine adhesion in group B was lower than that in group A, the recovery rate of menstruation in group B was higher than that in group A, there were statistically significant differences （ P〈O. 05 ） ; endometrial thickness in group B was statistically significantly thicker than that in group A （P〈0.05） ; there was no statistically significant difference in the incidence rate of adverse reactions between the two groups （P〉0.05） . Conclusion Estradiol valerate （9 mg per day） can achieve good curative effect used for the patients after hysteroscopic surgery, which can promote menstrual recovery and endometrial hyperplasia, and effectively prevent intrauterine readhesion.
出处
《中国妇幼保健》
CAS
2015年第30期5136-5138,共3页
Maternal and Child Health Care of China
关键词
戊酸雌二醇
宫腔粘连
宫腔镜术
Estradiol valerate
Intrauterine adhesion
Hysteroscopic surgery
作者简介
通讯作者E-mail：chiyugang@163．com
