摘要
目的探讨年轻女性乳腺癌患者的临床特点及治疗方法。方法回顾性分析郑州大学人民医院2010年1月至2014年3月收治的115例年轻(≤35岁)女性乳腺癌患者的临床资料,随机选取同期老年(≥60岁)女性乳腺癌患者115例作为对照组,对比分析两组患者肿瘤分期、淋巴结转移情况、病理类型、免疫组化指标、分子分型、手术方式等。结果年轻组中晚期乳腺癌患者比例高于老年组(P<0.05)。年轻组淋巴结转移75例(65.2%),老年组淋巴结转移43例(42.6%),两组差异具有统计学意义(P<0.05)。两组病理类型分布差异无统计学意义(P>0.05)。年轻组ER阳性率低于老年组(P<0.05),PR、HER2阳性率组间差异无统计学意义(P>0.05)。年轻组中Luminal A型乳腺癌患者所占比例低于老年组,但三阴性乳腺癌所占比例高于老年组(P<0.05)。年轻组患者保乳手术率高于老年组(P<0.05)。结论年轻乳腺癌分期晚、淋巴结转移多见;ER阳性率高;Luminal A型及三阴性乳腺癌所占比例较高。年轻患者更倾向于保乳手术治疗。
Objective To explore the clinical features and treatment of young women with breast cancer. Methods The clinical date of 115 female cases of breast cancer with age ≤35 years who were treated in People＇ s Hospital of Zhengzhou University from January of 2010 to March of 2014 were retrospectively ananlyzed and compared with those of 115 female cases of breast cancer with age 〉~60 years as control group selected randomly during the same period. The tumor stage, pathological type, lymph node metastasis, immunohistochemical index, molecular classification, operation method of two groups were compared. Results The number of middle - late breast cancer patients in young group were significantly higher than elderly group （ P 〈 0. 05）. There were 75 patients （65.2%） with lymph node metastasis in young group and 43 cases （42.6%） in elderly group, and the difference was statistically significant （ P 〈 0. 05 ）. Pathological types in the two groups were not statistically different （ P 〉 0. 05 ）. ER positive rate of young group was lower than the elderly group （ P 〈 0. 05 ）. There was no diffrence in PR, HER2 positive rates （P 〉 0. 05 ）. The proportion of Luminal A type in young group was significantly lower than elderly group （ P 〉 0. 05）. The proportion of triple - negative breast cancer was higher than elderly group （P 〈 0. 05）. The rate of breast - conserving therapy in young group was higher than elderly group （ P 〉 0. 05 ）. Conclusion Breast cancer in young women had late staging, high proportion of lymph node metastasis, high positive rate of ER, high proportion of Luminal A type and triple - nega- tive breast cancer. Young patients with breast cancer are more prone to breast - conserving therapy.
出处
《河南医学研究》
CAS
2015年第11期21-23,共3页
Henan Medical Research
关键词
乳腺癌
年轻
女性
病理类型
分子分型
breast cancer
youth
women
pathological type
molecular classification
作者简介
通讯作者：尤伟，E—mail：yw@yueh．me。
