摘要
目的探讨小儿哮喘急性发作期给予吸入用布地奈德混悬液联合硫酸沙丁胺醇气雾剂雾化吸入治疗的临床效果及肺功能的改善情况。方法将我院确诊的支气管哮喘急性发作期患儿60例随机数字表法分为对照组和观察组,每组30例。对照组患儿单纯给予硫酸沙丁胺醇气雾剂进行雾化吸入治疗,观察组患儿给予吸入用布地奈德混悬液联合硫酸沙丁胺醇气雾剂进行雾化吸入治疗,对比2组患儿治疗后的临床效果、肺功能改善情况及并发症的发生率。结果观察2组患儿治疗后2h内喘息、呼吸困难、咳嗽和肺部哮鸣音等临床症状的缓解时间及住院时间明显短于对照组;2组患儿进行治疗后的FEV1、PEF、FVC明显高于治疗前,并且观察组患儿第1秒用力呼气容积(FEV1)、最大呼气流速峰值(PEF)、用力肺活量(FVC)的改善程度明显好于对照组,差异有统计学意义(P<0.05)。2组患儿均未发生明显的不良反应。结论支气管哮喘急性发作期的患儿给予吸入用布地奈德混悬液和硫酸沙丁胺醇气雾剂联合雾化治疗,能明显改善患者的临床症状和体征,明显改善患者的肺功能指标,并且未发现严重的不良反应,临床效果确切,安全可靠,值得广泛应用。
Objective To analyze the clinical efficacy and the improvement of pulmonary function of the treatment for children with acute asthma by using pulmicort respules and salbutamol sulphate aerosol inhala‐tion.Methods Sixty cases of children diagnosed as acute phase of asthma were collected and randomly divided into observation group and control group ,30 cases in each .The children in the control group were treated with salbu‐tamol sulphate aerosol inhalation only ,while those in the observation group received Pulmicort Respules addition‐ally based on the control group .The clinical efficacy ,the improvement of pulmonary function and the complica‐tions were compared in the two groups.Results The hospitalization time and the time of symptoms remission , such as dyspnea ,cough and wheezing after 2‐hour‐treatment were significantly shorter in the observation group than those in the control group .The levels of the forced expiratory volume in one second （FEV1） ,the peak expir‐atory flow （PEF） and the forced vital capacity （FVC） were improved after treatment in both the two groups . While the records of those indications were better in the observation group ,compared with the control group （P〈0 .05） .No significant adverse reaction occurred in the two groups .Conclusion Inhalation therapy of children with acute asthma using pulmicort respules combined with salbutamol sulphate aerosol inhalation ,which was found no serious adverse reactions ,are able to improve the clinical efficacy and the pulmonary function .Based on the exact , safe and reliable efficacy ,the combined use of these two kinds of drugs is worthy of wide application.
出处
《山西医药杂志》
CAS
2015年第18期2103-2105,共3页
Shanxi Medical Journal
基金
四川省攀枝花市科技基金(2013091953)
关键词
布地奈德
投药
吸入
哮喘
Budesonide
Administration,inhalation
Asthma
